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39 条记录 (耗时 0.045 秒)

    Pancreatic polypeptide family motifs and polypeptides comprising the same
    3.
    发明授权
    Pancreatic polypeptide family motifs and polypeptides comprising the same 失效
    胰多肽家族基序和包含其的多肽

    公开(公告)号：US08603969B2

    公开(公告)日：2013-12-10

    申请号：US11055098

    申请日：2005-02-11

    申请人： Odile Esther Levy ,  Carolyn M. Jodka ,  Soumitra S. Ghosh ,  David G. Parkes ,  Richard A. Pittner ,  Lawrence J. D'Souza ,  John S. Ahn ,  Kathryn S. Prickett

    发明人： Odile Esther Levy ,  Carolyn M. Jodka ,  Soumitra S. Ghosh ,  David G. Parkes ,  Richard A. Pittner ,  Lawrence J. D'Souza ,  John S. Ahn ,  Kathryn S. Prickett

    IPC分类号： A61K38/22

    CPC分类号： C07K14/575 ,  A61K38/00 ,  C07K14/475

    摘要： The present invention relates to novel Pancreatic Polypeptide Family (“PPF”) polypeptides. The PPF polypeptides of the invention generally include at least two PPF motif, have at least 50% sequence identity to PYY (3-36) over its length and will generally retain, at least in part, a biological activity of a PP, PYY or NPY. Preferred PPF polypeptides of the invention are those having a potency in one of the assays described herein (preferably food intake, gastric emptying, pancreatic secretion, or weight reduction assays) which is greater than the potency of PP, NPY, PYY, or PYY(3-36) in that same assay. In one aspect, the PPF polypeptides of the invention include novel PYY analog polypeptides. In another aspect, the PPF polypeptides of the invention include PPF chimeric polypeptides including a fragment of a PP family polypeptide linked to a second PP family polypeptide, wherein each of the first and second fragments includes a PPF motif. Methods of using the PPF polypeptides of the invention, and pharmaceutical compositions including the PPF polypeptides of the invention are also disclosed.

    摘要翻译： 本发明涉及新型胰腺多肽家族（“PPF”）多肽。 本发明的PPF多肽通常包括至少两个PPF基序，其长度与PYY（3-36）具有至少50％的序列同一性，并且通常至少部分地保留PP，PYY的生物学活性或 NPY。 本发明优选的PPF多肽是在本文所述测定之一（优选食物摄取，胃排空，胰腺分泌或重量减轻试验）中具有效力的那些，其大于PP，NPY，PYY或PYY的效力（ 3-36）。 一方面，本发明的PPF多肽包括新的PYY类似物多肽。 在另一方面，本发明的PPF多肽包括PPF嵌合多肽，其包括与第二PP家族多肽连接的PP家族多肽的片段，其中第一和第二片段中的每一个包括PPF基序。 还公开了使用本发明的PPF多肽的方法和包括本发明的PPF多肽的药物组合物。

    Exendins and exendin agonists modified with albumin
    10.
    发明授权
    Exendins and exendin agonists modified with albumin 有权
    用白蛋白修饰的毒蜥外泌肽和毒蜥外泌激素

    公开(公告)号：US07608692B2

    公开(公告)日：2009-10-27

    申请号：US12101689

    申请日：2008-04-11

    申请人： Kathryn S. Prickett ,  Andrew A. Young

    发明人： Kathryn S. Prickett ,  Andrew A. Young

    IPC分类号： A61K38/38 ,  A61K38/28 ,  A61K38/00

    CPC分类号： C07K14/605 ,  A61K47/60

    摘要： Modified exendins and exendin agonists having an exendin or exendin agonist linked to one or more polyethylene glycol polymers, for example, and related formulations and dosages and methods of administration thereof are provided. These modified exendins and exendin agonists, compositions and methods are useful in treating diabetes and conditions that would be benefited by lowering plasma glucose or delaying and/or slowing gastric emptying or inhibiting food intake.

    摘要翻译： 提供了具有与一种或多种聚乙二醇聚合物连接的毒蜥外泌肽或毒蜥外泌激素的修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，以及相关的制剂和剂量以及施用方法。 这些修饰的毒蜥外泌肽和毒蜥外泌肽激动剂，组合物和方法可用于治疗通过降低血浆葡萄糖或延迟和/或减缓胃排空或抑制食物摄取而受益的糖尿病和病症。