公开(公告)号：US20110269720A1

公开(公告)日：2011-11-03

申请号：US12768913

申请日：2010-04-28

申请人： Christopher M. Hobot ,  Randall V. Sparer ,  Mark E. Hughes ,  William Ferris

发明人： Christopher M. Hobot ,  Randall V. Sparer ,  Mark E. Hughes ,  William Ferris

IPC分类号： A61K31/65 ,  A61P31/04

CPC分类号： A61K31/495 ,  A61K31/65 ,  A61K2300/00

摘要： Methods and kits for treating infection associated with implantation of a medical device use of minocycline and rifampin microparticles. The microparticles, in a suitable medium, can be injected in a patient in proximity to the device. The drugs may be configured to be released from the polymer matrix in a controlled manner by manipulation of the properties of the polymer forming the microparticle. By injecting the drugs in the form of microparticles, the drugs can be distributed in a manner so that the entire pocket is protected without affecting device function. The microparticles can be produced aseptically without affecting the manufacturing of the device.

摘要翻译： 用于治疗与植入医疗器械相关的感染的方法和试剂盒使用米诺环素和利福平微粒。 在合适的介质中的微粒可以被注射到设备附近的患者体内。 药物可以被配置为通过操纵形成微粒的聚合物的性质以受控的方式从聚合物基质释放。 通过以微粒的形式注射药物，药物可以以使得整个口袋被保护而不影响装置功能的方式分布。 微粒可以无菌地生产，而不影响器件的制造。

公开(公告)号：US5752965A

公开(公告)日：1998-05-19

申请号：US734113

申请日：1996-10-21

申请人： Ralph T. Francis ,  Mark E. Hughes ,  Anne E. Claeson ,  Joel Cooper

发明人： Ralph T. Francis ,  Mark E. Hughes ,  Anne E. Claeson ,  Joel Cooper

IPC分类号： A61B17/11 ,  A61B17/00 ,  A61B17/072 ,  A61B17/10

CPC分类号： A61B17/07207 ,  A61B17/00491 ,  A61B17/07292 ,  A61B2017/00004

摘要： An apparatus and method for providing reinforced surgical fastener suture lines to prevent tissue tearing and fluid leakage following the creation of an anastomosis, the closing of margins following the removal of diseased tissue, and/or the ligating and dividing of individual blood vessels. A retainer assembly is provided having an alignment frame and a pressure equalization member. The alignment frame includes an internally disposed receiving area for housing the pressure equalization member and a pair of guide channels disposed in fluid communication with the receiving area for guiding the jaw members of a surgical fastener applying device into contact with pledget material disposed within the receiving area. Any number of surgical fastener applying devices may be retrofitted to provide reinforced surgical fastener suture lines by applying an adhesive along the length of the pledget material, positioning the jaw members of a surgical fastener applying device within the guide channels, and closing the surgical fastener applying device such that the jaw members are brought into compressed contact with the adhesive-laden pledget material. The surgical fastener applying device may then be opened with the pledget material releasibly attached to the jaw members, the jaw members positioned about a section of body tissue, and the surgical fastener applying device fired to create a reinforced suture line boasting reduced tissue tearing and reduced fluid leakage.

摘要翻译： 一种用于提供加强手术紧固件缝线的装置和方法，以防止在产生吻合之后的组织撕裂和流体泄漏，在移除患病组织之后关闭边缘，和/或单独血管的结扎和分开。 提供具有对准框架和压力均衡构件的保持器组件。 对准框架包括用于容纳压力平衡构件的内部设置的容纳区域和与接收区域流体连通地布置的一对引导通道，用于引导手术紧固件施加装置的钳口构件与布置在接收区域内的抹灰材料接触 。 任何数量的手术紧固件施加装置可以被改进以通过沿着所述绒毛材料的长度施加粘合剂来将增强的外科紧固件缝合线提供，以将手术紧固件施加装置的钳口构件定位在引导通道内，并且关闭手术紧固件施加 装置，使得钳口构件与粘合剂填充材料压缩接触。 手术紧固件施加装置然后可以打开，其中可释放地附接到钳口构件的钳形材料，夹钳构件围绕身体组织的一部分定位，并且手术紧固件施加装置被点燃以产生加强的缝合线，其具有减少的组织撕裂并减少 流体泄漏。