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1.发明申请公开(公告)号：US20170112930A1
公开(公告)日：2017-04-27
申请号：US15400355
申请日：2017-01-06
发明人： Daisuke KAMEOKA , Masaya Yasutake
IPC分类号： A61K39/395 , A61K47/18
CPC分类号： A61K39/39591 , A61K9/0019 , A61K9/08 , A61K47/18 , A61K47/183 , C07K16/2866 , C07K2317/94
摘要： Addition of argininamide or valinamide to a highly concentrated antibody solution was found to lead to remarkable stabilization, in particular, stabilization against photostress.
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2.发明授权公开(公告)号：US10898572B2
公开(公告)日：2021-01-26
申请号：US15400355
申请日：2017-01-06
发明人： Daisuke Kameoka , Masaya Yasutake
IPC分类号： A61K39/395 , A61K47/18 , A61K9/08 , C07K16/28 , A61K9/00
摘要： Addition of argininamide or valinamide to a highly concentrated antibody solution was found to lead to remarkable stabilization, in particular, stabilization against photostress.
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公开(公告)号：US20230210991A1
公开(公告)日：2023-07-06
申请号：US17926313
申请日：2021-05-28
发明人： Daisuke Kameoka , Masaya Yasutake , Masakazu Fukuda , Atsushi Watanabe , Tomoyuki Igawa , Chifumi Imai , Akira Hayasaka
CPC分类号： A61K39/39591 , A61K9/08 , A61K9/19 , A61K47/10 , A61K47/22 , A61K47/183 , C07K16/2866 , A61K2039/54 , C07K2317/565
摘要： In one non-limiting embodiment, the present disclosure is an antibody-containing formulation comprising an anti-IL-6 receptor antibody as an active ingredient, and contains histidine-aspartate buffer or histidine-glutamate buffer, Poloxamer 188, and arginine, and has a pH of 5.5 to 6.6. In one non-limiting embodiment, the present disclosure is a method of stabilizing an antibody-containing solution, a method of suppressing antibody association (e.g., dimerization), and a method of suppressing the generation of insoluble particles, wherein L-aspartic acid or L-glutamic acid, and optionally, Poloxamer 188 are added.
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