公开(公告)号：US20090076130A1

公开(公告)日：2009-03-19

申请号：US11855416

申请日：2007-09-14

申请人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

发明人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

IPC分类号： A61K31/353 ,  A61P25/28 ,  C07D311/32 ,  A61P35/00

CPC分类号： C07D311/32

摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

摘要翻译： 本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。 该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。 特别地，本发明的化合物可用作抗神经变性疾病和人脊髓性肌萎缩（SMA）的药剂。

公开(公告)号：US08008344B2

公开(公告)日：2011-08-30

申请号：US11855416

申请日：2007-09-14

申请人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

发明人： Chung-Yang Huang ,  Chia-Nan Chen ,  Wei-Jan Huang ,  Chih-Hsiang Huang ,  Li-Ling Chi ,  Chiou-Ping You

IPC分类号： A61K31/352 ,  C07D311/32

CPC分类号： C07D311/32

摘要： The invention relates to a compound represented by the following formula (I): and pharmaceutically acceptable salts, stereoisomers, enantiomers, prodrugs and solvates thereof. The compounds are useful as an agent for enhancing the neurite outgrowth and preventing or treating of diseases associated with HDAC in particular, tumor or cell proliferative diseases. In particular, the compounds of the invention can be used as an agent for anti-neurodegenerative diseases and human spinal muscular atrophy (SMA).

摘要翻译： 本发明涉及由下式（I）表示的化合物及其药学上可接受的盐，立体异构体，对映异构体，前药和溶剂合物。 该化合物可用作增强神经突生长和预防或治疗与HDAC相关的疾病，特别是肿瘤或细胞增殖性疾病的药剂。 特别地，本发明的化合物可用作抗神经变性疾病和人脊髓性肌萎缩（SMA）的药剂。