公开(公告)号：US20120141523A1

公开(公告)日：2012-06-07

申请号：US13388757

申请日：2010-08-03

申请人： Cindy Castado ,  Sophie Marie Jeanne Valentine Germain ,  Melanie Gilbert

发明人： Cindy Castado ,  Sophie Marie Jeanne Valentine Germain ,  Melanie Gilbert

IPC分类号： A61K39/085 ,  A61P31/04 ,  C07K14/31

CPC分类号： A61K39/085 ,  C07K14/31 ,  C07K2319/00

摘要： The present application relates to an immunogenic composition comprising a fragment of a staphylococcal Isd protein such as IsdA, IsdB, IsdC or IsdH which comprises a NEAT domain. Fusion proteins comprising a NEAT domain of a first staphylococcal Isd protein and a NEAT domain from a second Isd protein are also disclosed as well as fusion proteins comprising a NEAT domain of a staphylococcal Isd protein involved in an iron/heme uptake system and a ligand binding domain of a staphylococcal extracellular component binding protein, for example ClfA, ClfB, SdrC, SdrD or SdrE.

摘要翻译： 本申请涉及包含葡萄球菌Isd蛋白片段的免疫原性组合物，所述葡萄球菌Isd蛋白质包括NEAT结构域，所述IsdA，IsdB，IsdC或IsdH包含NEAT结构域。 还公开了包含第一葡萄球菌Isd蛋白的NEAT结构域和来自第二Isd蛋白的NEAT结构域的融合蛋白以及包含参与铁/血红素吸收系统和配体结合的葡萄球菌Isd蛋白的NEAT结构域的融合蛋白 葡萄球菌胞外成分结合蛋白的结构域，例如ClfA，ClfB，SdrC，SdrD或SdrE。