Isoindolin-1-one derivatives
    1.
    发明授权
    Isoindolin-1-one derivatives 失效
    ISOINDOLIN-1-ONE衍生物

    公开(公告)号:US3987174A

    公开(公告)日:1976-10-19

    申请号:US527031

    申请日:1974-11-25

    CPC分类号: C07D209/48

    摘要: Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxy-propoxy group, and optionally substituted in the 5-and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as anti-arrhythmic agents.

    Naphthyridine derivatives
    2.
    发明授权
    Naphthyridine derivatives 失效
    萘啶衍生物

    公开(公告)号:US4016274A

    公开(公告)日:1977-04-05

    申请号:US623359

    申请日:1975-10-17

    IPC分类号: C07D519/00 C07D401/14

    CPC分类号: C07D519/00

    摘要: Compounds of the formula: ##STR1## wherein one of the symbols =X-- represents =N-- and the other three each represent a group ##STR2## in which Y represents hydrogen, halogen, alkyl, alkoxy, cyano or nitro, at least two of the symbols representing hydrogen, Z represents hydrogen, halogen, alkyl, alkoxy, trifluoromethyl or nitro, and (i) n represents zero and R represents hydrogen, alkyl, alkenyl, alkynyl, hydroxyalkyl or phenyl, or (ii) n represents 1 and R represents alkyl, hydroxyalkyl or phenyl, are new compounds possessing pharmacological properties; they are particularly active as tranquilizers and anti-convulsant agents.

    摘要翻译: 其中符号之一= X表示= N-,其余三个表示其中Y表示氢,卤素,烷基,烷氧基,氰基或硝基的基团,至少两个 表示氢的符号,Z表示氢,卤素,烷基,烷氧基,三氟甲基或硝基,(i)n表示0,R表示氢,烷基,烯基,炔基,羟烷基或苯基,或(ii)n表示1和 R代表烷基,羟基烷基或苯基,是具有药理学性质的新化合物; 它们作为镇静剂和抗惊厥药物是特别活跃的。

    Isoindolin-1-one derivatives
    4.
    发明授权
    Isoindolin-1-one derivatives 失效
    异吲哚啉-1-酮衍生物

    公开(公告)号:US4054654A

    公开(公告)日:1977-10-18

    申请号:US669730

    申请日:1976-03-23

    CPC分类号: C07D209/48 Y10S514/821

    摘要: Isoindolin-1-one derivatives substituted on the nitrogen atom in the 2-position by an unsubstituted or substituted phenyl radical or a heterocyclic radical having aromatic characteristics, substituted in the 3-position by a 3-amino(or substituted amino)-2-hydroxy-propoxy group, and optionally substituted in the 5- and/or 6-positions by one or two alkoxy radicals or optionally substituted in the 5- and 6-positions by a methylenedioxy radical, possess pharmacodynamic properties, and are especially useful as antiarrhythmic agents.

    摘要翻译: 通过未取代或取代的苯基或具有芳香特性的杂环基取代2-位的氮原子上的异二氢吲哚-1-酮衍生物,3-位氨基(或取代的氨基)-2- 羟基 - 丙氧基,并且任选地在5-和/或6-位被一个或两个烷氧基取代或任选地在5-和6-位被亚甲二氧基取代,具有药效学特性,并且特别可用作抗心律不齐 代理商

    Anti-arrhythmic compositions containing isoindoline derivatives
    6.
    发明授权
    Anti-arrhythmic compositions containing isoindoline derivatives 失效
    含有异二氢吲哚衍生物的抗心律不齐组合物

    公开(公告)号:US4000306A

    公开(公告)日:1976-12-28

    申请号:US559039

    申请日:1975-03-17

    IPC分类号: C07D209/48 A61K31/40

    CPC分类号: C07D209/48

    摘要: Isoindolin-1-one derivatives carrying on the nitrogen atom in the 2-position a phenyl or pyridyl radical, optionally carrying one or two substituents selected from halogen, alkyl (C.sub.1 -C.sub.4), alkoxy (C.sub.1 -C.sub.4), cyano and trifluoromethyl, and in the 3-position a grouping --O--T--NR.sub.1 R.sub.2 wherein T is alkylene (C.sub.2 -C.sub.6), and R.sub.1 and R.sub.2 represent hydrogen or alkyl (C.sub.1 -C.sub.4), are new compounds possessing pharmacodynamic properties and are useful as anti-arrhythmic agents.

    摘要翻译: 携带2位氮原子的苯并或吡啶基的异二氢吲哚-1-酮衍生物,任选地带有一个或两个选自卤素,烷基(C 1 -C 4),烷氧基(C 1 -C 4),氰基和三氟甲基的取代基, 在3位是分组-OT-NR1R2,其中T是亚烷基(C2-C6),R1和R2代表氢或烷基(C1-C4),是具有药效学性质的新化合物,可用作抗心律失常剂 。

    Naphtyridine derivatives
    10.
    发明授权
    Naphtyridine derivatives 失效
    萘啶衍生物

    公开(公告)号:US4131674A

    公开(公告)日:1978-12-26

    申请号:US843369

    申请日:1977-10-19

    CPC分类号: C07D471/04

    摘要: Heterocyclic compounds of the formula: ##STR1## wherein the pyrroline ring and the symbols X.sub.1 and X.sub.2 together form an unsubstituted or substituted isoindoline nucleus, or a 6,7-dihydro-5H-pyrrolo[3,4-b]pyrazine, 6,7-dihydro-5H-pyrrolo[3,4-b]pyridine or 2,3,6,7-tetrahydro-5H-1,4-oxathiino[2,3-c]pyrrole nucleus, the 1,8-naphthyridin-2-yl nucleus is unsubstituted or substituted, and the grouping --NR.sub.1 R.sub.2 is an amino or substituted amino group, are new compounds which are active as tranquillizers, hypnotics, anti-convulsant agents and anti-spasmodics.

    摘要翻译: 其中吡咯啉环和符号X1和X2一起形成未取代或取代的异吲哚啉核的6,7-二氢-5H-吡咯并[3,4-b]吡嗪6, 7-二氢-5H-吡咯并[3,4-b]吡啶或2,3,6,7-四氢-5H-1,4-氧硫杂环丁烷并[2,3-c]吡咯核,1,8-萘啶 - 2-基核是未取代或取代的,并且-NR1R2基团是氨基或取代的氨基,是作为镇静剂,催眠药,抗惊厥剂和抗痉挛剂起作用的新化合物。