公开(公告)号：US20090270444A1

公开(公告)日：2009-10-29

申请号：US11718892

申请日：2005-11-17

申请人： Colin David Eldred ,  John Edward Robinson ,  Alison Judith Steel

发明人： Colin David Eldred ,  John Edward Robinson ,  Alison Judith Steel

IPC分类号： A61K31/4375 ,  C07D471/04 ,  A61P37/08

CPC分类号： C07D471/04

摘要： There are provided according to the invention novel compounds of formula (I) and pharmaceutically acceptable salts and solvates thereof, wherein: R1 is phenyl which may be unsubstituted or substituted by one or two substituents selected from fluorine, chlorine, C1-2alkoxy-, —CN; phenyl fused to a 5-membered saturated ring containing one oxygen atom; pyridinyl which may be unsubstituted or substituted by one or two substituents selected from fluorine or chlorine; or C-linked pyrazolyl which may be unsubstituted or substituted by the substituent C1-2alkyl; R2 is C1-4alkyl; R3 is C1-2alkyl; and n is 0, 1 or 2.

摘要翻译： 根据本发明，提供新的式（I）化合物及其药学上可接受的盐和溶剂化物，其中：R1是可以是未取代的或被一个或两个选自氟，氯，C 1-2烷氧基 - ， - CN; 与含有一个氧原子的5元饱和环稠合的苯基; 吡啶基，其可以是未取代的或被一个或两个选自氟或氯的取代基取代; 或C连接的吡唑基，其可以是未取代的或被取代基C 1-2烷基取代; R2是C1-4烷基; R3是C1-2烷基; n为0,1或2。