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公开(公告)号:US20220133753A1
公开(公告)日:2022-05-05
申请号:US17340665
申请日:2021-06-07
申请人: Comet Therapeutics, Inc. , RIJKSUNIVERSITEIT GRONINGEN , ACADEMISCH ZIEKENHUIS GRONINGEN , Oregon Health & Science University
发明人: Gregor KOSEC , Ajda Podgorsek BERKE , Hrvoje PETKOVIC , Oda Cornelia Maria SIBON , Balaji SRINIVASAN , Susan J. HAYFLICK
IPC分类号: A61K31/661 , A61P1/14
摘要: Methods and pharmaceutical compositions for use in treating diseases associated with insufficient activity of the pantothenate kinase enzyme (e.g., CASTOR diseases) are disclosed. The methods and compositions involve an effective amount of an active derivative of 4′-phosphopantetheine.
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2.
公开(公告)号:US20190255079A1
公开(公告)日:2019-08-22
申请号:US16309983
申请日:2017-06-16
申请人: ACIES BIO D.O.O. , RIJKSUNIVERSITEIT GRONINGEN , ACADEMISCH ZIEKENHUIS GRONINGEN , Oregon Health & Science University
发明人: Gregor KOSEC , Ajda Podgorsek BERKE , Hrvoje PETKOVIC , Oda Cornelia Maria SIBON , Balaji SRINIVASAN , Susan J. HAYFLICK
IPC分类号: A61K31/661 , A61P1/14
摘要: Methods and pharmaceutical compositions for use in treating diseases associated with insufficient activity of the pantothenate kinase enzyme (e.g., CASTOR diseases) are disclosed. The methods and compositions involve an effective amount of an active derivative of 4′-phosphopantetheine.
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公开(公告)号:US20180118767A1
公开(公告)日:2018-05-03
申请号:US15850252
申请日:2017-12-21
发明人: Branko JENKO , Gregor KOSEC , Hrvoje PETKOVIC , Ajda Podgorsek BERKE , Jerca PAHOR , Alen CUSAK , Oda Cornelia Maria SIBON , Balaji SRINIVASAN
IPC分类号: C07F9/09
摘要: The invention relates to (S)-acyl-4′-phosphopantetheine derivatives, methods of their synthesis, and related medical uses of such compounds. Preferred medical uses relate to the treatment of neurodegenerative diseases, such as PKAN.
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