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1.发明授权Portable dual field gradient force multichannel flow cytometer device with a dual wavelength low noise detection scheme 有权便携式双场梯度力多通道流式细胞仪器，具有双波长低噪声检测方案公开(公告)号：US08293089B1
公开(公告)日：2012-10-23
申请号：US12610409
申请日：2009-11-02
申请人： Conrad D. James , Paul C. Galambos , Mark S. Derzon , Darin C. Graf , Kenneth R. Pohl , Chris J. Bourdon
发明人： Conrad D. James , Paul C. Galambos , Mark S. Derzon , Darin C. Graf , Kenneth R. Pohl , Chris J. Bourdon
CPC分类号： B03C1/288 , B03C1/30 , B03C5/005 , B03C5/026 , B03C2201/18
摘要： Systems and methods for combining dielectrophoresis, magnetic forces, and hydrodynamic forces to manipulate particles in channels formed on top of an electrode substrate are discussed. A magnet placed in contact under the electrode substrate while particles are flowing within the channel above the electrode substrate allows these three forces to be balanced when the system is in operation. An optical detection scheme using near-confocal microscopy for simultaneously detecting two wavelengths of light emitted from the flowing particles is also discussed.
摘要翻译： 讨论了组合介电电泳，磁力和流体动力以操纵形成在电极基底顶部的通道中的颗粒的系统和方法。 当在电极基板上方的通道中流动粒子时，在电极基板下面接触的磁体允许这三个力在系统运行时平衡。 还讨论了使用近共聚焦显微镜同时检测从流动颗粒发射的两个波长的光的光学检测方案。
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公开(公告)号：US07713395B1
公开(公告)日：2010-05-11
申请号：US11401714
申请日：2006-04-11
IPC分类号： G01N27/453
CPC分类号： B03C5/026
摘要： A dielectrophoretic columnar focusing device uses interdigitated microelectrodes to provide a spatially non-uniform electric field in a fluid that generates a dipole within particles in the fluid. The electric field causes the particles to either be attracted to or repelled from regions where the electric field gradient is large, depending on whether the particles are more or less polarizable than the fluid. The particles can thereby be forced into well defined stable paths along the interdigitated microelectrodes. The device can be used for flow cytometry, particle control, and other process applications, including cell counting or other types of particle counting, and for separations in material control.
摘要翻译： 介电电泳柱状聚焦装置使用交叉指向的微电极在流体中的颗粒内产生偶极子的流体中提供空间不均匀的电场。 电场导致颗粒被电场梯度大的区域吸引或排斥，这取决于颗粒是否比流体多或少极化。 因此，颗粒可以沿着交叉指示的微电极被强制进入明确定义的稳定路径。 该装置可用于流式细胞术，粒子控制和其他过程应用，包括细胞计数或其他类型的颗粒计数，以及材料控制中的分离。
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公开(公告)号：US08912502B2
公开(公告)日：2014-12-16
申请号：US13559370
申请日：2012-07-26
摘要： A neutron detector with monolithically integrated readout circuitry, including: a bonded semiconductor die; an ion chamber formed in the bonded semiconductor die; a first electrode and a second electrode formed in the ion chamber; a neutron absorbing material filling the ion chamber; and the readout circuitry which is electrically coupled to the first and second electrodes. The bonded semiconductor die includes an etched semiconductor substrate bonded to an active semiconductor substrate. The readout circuitry is formed in a portion of the active semiconductor substrate. The ion chamber has a substantially planar first surface on which the first electrode is formed and a substantially planar second surface, parallel to the first surface, on which the second electrode is formed. The distance between the first electrode and the second electrode may be equal to or less than the 50% attenuation length for neutrons in the neutron absorbing material filling the ion chamber.
摘要翻译： 一种具有单片集成读出电路的中子检测器，包括：键合半导体管芯; 形成在所述键合半导体管芯中的离子室; 形成在所述离子室中的第一电极和第二电极; 填充离子室的中子吸收材料; 以及电耦合到第一和第二电极的读出电路。 键合的半导体管芯包括结合到有源半导体衬底的蚀刻半导体衬底。 读出电路形成在有源半导体衬底的一部分中。 离子室具有基本上平面的第一表面，第一电极形成在其上，并且平行于第一表面的基本平坦的第二表面，在其上形成第二电极。 第一电极和第二电极之间的距离可以等于或小于填充离子室的中子吸收材料中的中子的50％衰减长度。
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公开(公告)号：US20130020492A1
公开(公告)日：2013-01-24
申请号：US13559370
申请日：2012-07-26
IPC分类号： G01T3/00
摘要： A neutron detector with monolithically integrated readout circuitry, including: a bonded semiconductor die; an ion chamber formed in the bonded semiconductor die; a first electrode and a second electrode formed in the ion chamber; a neutron absorbing material filling the ion chamber; and the readout circuitry which is electrically coupled to the first and second electrodes. The bonded semiconductor die includes an etched semiconductor substrate bonded to an active semiconductor substrate. The readout circuitry is formed in a portion of the active semiconductor substrate. The ion chamber has a substantially planar first surface on which the first electrode is formed and a substantially planar second surface, parallel to the first surface, on which the second electrode is formed. Desirably, the distance between the first electrode and the second electrode may be equal to or less than the 50% attenuation length for neutrons in the neutron absorbing material filling the ion chamber.
摘要翻译： 一种具有单片集成读出电路的中子检测器，包括：键合半导体管芯; 形成在所述键合半导体管芯中的离子室; 形成在所述离子室中的第一电极和第二电极; 填充离子室的中子吸收材料; 以及电耦合到第一和第二电极的读出电路。 键合的半导体管芯包括结合到有源半导体衬底的蚀刻半导体衬底。 读出电路形成在有源半导体衬底的一部分中。 离子室具有基本上平面的第一表面，第一电极形成在其上，并且平行于第一表面的基本平坦的第二表面，在其上形成第二电极。 理想地，第一电极和第二电极之间的距离可以等于或小于填充离子室的中子吸收材料中的中子的50％的衰减长度。
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