公开(公告)号：US20080188449A1

公开(公告)日：2008-08-07

申请号：US11667696

申请日：2005-11-15

申请人： Craig M. Crews ,  Stephanie J. Quinn ,  Stefan Somlo ,  Dayne Okuhara

发明人： Craig M. Crews ,  Stephanie J. Quinn ,  Stefan Somlo ,  Dayne Okuhara

IPC分类号： A61K31/585 ,  A61P13/12 ,  C12N5/02 ,  C12Q1/02

CPC分类号： A61K31/366

摘要： In certain aspects, the invention relates to use of PKD2 agonists, such as triptolide and triptolide derivatives, to regulate calcium release. In other aspects, the invention relates to use of PKD2 agonists to treat or aid in the treatment of any condition in which a calcium channel, such as the gene product of PKD 1 and/or PKD2, is mutated; calcium signaling is abnormal; or both, such as polycystic kidney disease.

摘要翻译： 在某些方面，本发明涉及使用PKD2激动剂，例如雷公藤内酯和雷公藤内酯衍生物来调节钙的释放。 在其它方面，本发明涉及PKD2激动剂用于治疗或帮助治疗其中钙通道（例如PKD1和/或PKD2的基因产物）突变的任何病症的用途; 钙信号异常; 或两者，如多囊肾病。