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公开(公告)号：US07230015B2
公开(公告)日：2007-06-12
申请号：US11079327
申请日：2005-03-14
申请人： Craig P Smith , Michel P Rathbone , Margaret Petty , David Rampe
发明人： Craig P Smith , Michel P Rathbone , Margaret Petty , David Rampe
IPC分类号： A61K31/44
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
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公开(公告)号：US07179821B2
公开(公告)日：2007-02-20
申请号：US11079366
申请日：2005-03-14
申请人： Craig P Smith , Michel P Rathbone , Margaret Petty , David Rampe
发明人： Craig P Smith , Michel P Rathbone , Margaret Petty , David Rampe
IPC分类号： A61K31/44
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
摘要翻译： 式I的N-（吡啶基）-1H-吲哚-1-胺提供钾和钠通道的阻断性质的独特组合。 这些化合物可用于治疗脱髓鞘疾病和病症如多发性硬化，脊髓损伤，创伤性脑损伤和中风。 这些化合物也可用于中风康复，膀胱刺激和功能障碍的治疗，以及治疗神经性疼痛和趋化因子诱导的疼痛。
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公开(公告)号：US07534803B2
公开(公告)日：2009-05-19
申请号：US11236145
申请日：2005-09-27
IPC分类号： A61K31/44
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
摘要翻译： 式I的N-（吡啶基）-1H-吲哚-1-胺提供钾和钠通道的阻断性质的独特组合。 这些化合物可用于治疗脱髓鞘疾病和病症如多发性硬化，脊髓损伤，创伤性脑损伤和中风。 这些化合物也可用于中风康复，膀胱刺激和功能障碍的治疗，以及治疗神经性疼痛和趋化因子诱导的疼痛。
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公开(公告)号：US06967210B2
公开(公告)日：2005-11-22
申请号：US10076191
申请日：2002-02-14
IPC分类号： C07D401/12 , A61K20060101 , A61K31/4439 , A61P3/00 , A61P9/00 , A61P13/00 , A61P13/10 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00 , A61K31/44
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
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公开(公告)号：US20060025452A1
公开(公告)日：2006-02-02
申请号：US11236145
申请日：2005-09-27
申请人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
发明人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
IPC分类号： A61K31/4439
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
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公开(公告)号：US20050234105A1
公开(公告)日：2005-10-20
申请号：US11079366
申请日：2005-03-14
申请人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
发明人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
IPC分类号： C07D401/12 , A61K20060101 , A61K31/4439 , A61P3/00 , A61P9/00 , A61P13/00 , A61P13/10 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
摘要翻译： 式I的N-（吡啶基）-1H-吲哚-1-胺提供钾和钠通道的阻断性质的独特组合。 这些化合物可用于治疗脱髓鞘疾病和病症如多发性硬化，脊髓损伤，创伤性脑损伤和中风。 这些化合物也可用于中风康复，膀胱刺激和功能障碍的治疗，以及治疗神经性疼痛和趋化因子诱导的疼痛。
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公开(公告)号：US20050159456A1
公开(公告)日：2005-07-21
申请号：US11079327
申请日：2005-03-14
申请人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
发明人： Craig Smith , Michel Rathbone , Margaret Petty , David Rampe
IPC分类号： C07D401/12 , A61K20060101 , A61K31/4439 , A61P3/00 , A61P9/00 , A61P13/00 , A61P13/10 , A61P17/02 , A61P19/02 , A61P25/00 , A61P25/02 , A61P25/28 , A61P27/02 , A61P29/00 , A61P35/00
CPC分类号： A61K31/4439 , Y10S514/903
摘要： N-(Pyridinyl)-1H-indol-1-amines of formula I provide a unique combination of blocking properties for both the potassium and sodium channels. These compounds are useful for the treatment of Demyelinating Diseases and Conditions such as Multiple Sclerosis, Spinal Cord Injury, Traumatic Brain Injury and Stroke. The compounds are also useful for Stroke Rehabilitation, the treatment of Bladder Irritation and Dysfunction, and the treatment of Neuropathic Pain and Chemokine-Induced Pain.
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