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公开(公告)号：US20210251898A1
公开(公告)日：2021-08-19
申请号：US17142731
申请日：2021-01-06
发明人： Patrick BAUMHOF , Mariola FOTIN-MLECZEK , Regina HEIDENREICH , Michael J. HOPE , Edith JASNY , Sandra LAZZARO , Paulo Jia Ching LIN , Johannes LUTZ , Barbara MUI , Benjamin PETSCH , Susanne RAUCH , Kim Ellen SCHMIDT , Ying TAM
IPC分类号： A61K9/127 , A61K47/69 , A61P37/02 , A61P31/16 , A61K9/19 , A61K31/7105 , A61K39/145 , A61K39/39 , A61K47/14 , A61K31/16 , A61K31/23 , A61K31/40
摘要： The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
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公开(公告)号：US20200163878A1
公开(公告)日：2020-05-28
申请号：US16345299
申请日：2017-10-26
发明人： Patrick BAUMHOF , Mariola FOTIN-MLECZEK , Regina HEIDENREICH , Michael J. HOPE , Edith JASNY , Sandra LAZZARO , Paulo Jia Ching LIN , Johannes LUTZ , Barbara MUI , Benjamin PETSCH , Susanne RAUCH , Kim Ellen SCHWENDT , Ying TAM
IPC分类号： A61K9/127 , A61K39/39 , A61K9/19 , A61P37/02 , A61K31/7105 , A61P31/16 , A61K39/145 , A61K47/69 , A61K47/14
摘要： The invention relates to mRNA comprising lipid nanoparticles and their medical uses. The lipid nanoparticles of the present invention comprise a cationic lipid according to formula (I), (II) or (III) and/or a PEG lipid according to formula (IV), as well as an mRNA compound comprising an mRNA sequence encoding an antigenic peptide or protein. The invention further relates to the use of said lipid nanoparticles as vaccines or medicaments, in particular with respect to influenza or rabies vaccination.
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