公开(公告)号：US20250114307A1

公开(公告)日：2025-04-10

申请号：US18987494

申请日：2024-12-19

Applicant: CureVac SE

Inventor： Fabian Johannes EBER ,  Benyamin YAZDAN PANAH ,  Stefanie SEWING ,  Thomas KETTERER ,  Thorsten MUTZKE ,  Tilmann ROOS ,  Michael SONNTAG ,  Michael WIGGENHORN ,  Katharina KOLLAND

IPC: A61K9/16 ,  A61K39/00 ,  A61K39/145 ,  A61K48/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P33/02 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08

Abstract: The present invention is directed to a storage-stable formulation of long-chain RNA. In particular, the invention concerns a dry powder composition comprising a long-chain RNA molecule. The present invention is furthermore directed to methods for preparing a dry powder composition comprising a long-chain RNA molecule by spray-drying. The invention further concerns the use of such a dry powder composition comprising a long-chain RNA molecule in the preparation of pharmaceutical compositions and vaccines, to a method of treating or preventing a disorder or a disease, to first and second medical uses of such a dry powder composition comprising a long-chain RNA molecule and to kits, particularly to kits of parts, comprising such a dry powder composition comprising a long-chain RNA molecule.