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1.发明申请公开(公告)号：US20180153773A1
公开(公告)日：2018-06-07
申请号：US15737956
申请日：2016-06-28
申请人： DAICEL CORPORATION
CPC分类号： A61J3/10 , A61J3/06 , A61K9/2054 , A61K9/2063 , A61K9/2095 , A61K9/2826 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/36 , A61K47/38 , A61K47/42 , B30B11/34
摘要： The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that an outer layer-forming processing to provide an easy-to-take property is simply performed in a dry process without going through a wet condition so as to make the formed outer layer thicker; the easy-to-take solid preparation and the like.The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein an inner core tablet is coated with a compression-molded outer layer-forming agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising loading separately or simultaneously the inner core tablet and powder of the outer layer-forming agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently compression-molding them; a powder composition for coating a solid preparation for use in the above method, which comprises the water-soluble polymer and water-soluble sugar or sugar alcohol
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公开(公告)号：US20180243221A1
公开(公告)日：2018-08-30
申请号：US15739202
申请日：2016-06-28
申请人： DAICEL CORPORATION
IPC分类号： A61K9/20
CPC分类号： A61K9/2054 , A61K9/16 , A61K9/20 , A61K9/2018 , A61K9/2095 , A61K47/10 , A61K47/36 , A61K47/38
摘要： The purpose of present invention to provide a particulate composition that has the excellent provides moldability and useful as a composition that is used as an outer layer of a solid preparation, especially an easy-to-take solid preparation and the like; a composition for an easy-to-take solid preparation, which comprises the particulate composition and a gelling agent that will show slipperiness when it is brought into contact with water; and a solid preparation comprising the composition.The present invention relates to a particulate composition comprising sugar alcohol and a water-insoluble polymer; a composition for an easy-to-take solid preparation, which comprises the particulate composition and a gelling agent that will snow slipperiness when it is brought into contact with water; arid a solid preparation comprising the composition and the like.
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公开(公告)号：US20210154145A1
公开(公告)日：2021-05-27
申请号：US17045033
申请日：2019-04-02
申请人： Daicel Corporation
IPC分类号： A61K9/16
摘要： The problem to be solved by the present invention is to provide an easy-to-take granular preparation that forms a gel having low adhesiveness and appropriate hardness when brought into contact with water, exhibiting an improved swallowing as a result, and to provide a method for producing the granular preparation. The present invention pertains to an easy-to-take granular preparation including granules, each of which contains a sugar or a sugar alcohol and has a surface at least partially coated with a thickener, and to a method for producing the easy-to-take granular preparation, the method including granulating a composition that includes a sugar or a sugar alcohol using an aqueous solution of a thickener.
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公开(公告)号：US20180235876A1
公开(公告)日：2018-08-23
申请号：US15955958
申请日：2018-04-18
申请人： DAICEL CORPORATION
发明人： Takahiro HIRAMURA , Kiyoshi IKURA , Sae ITAYA , Tomohito OKABAYASHI , Naohiro HASHIKAWA , Anan SAKAGUCHI
CPC分类号： A61K9/0056 , A61K9/1635 , A61K9/1652 , A61K9/1694 , A61K9/2054
摘要： A method is used in the production of a disintegrative particulate composition including three components consisting of a first disintegrator component having sedimentation volume in water of 4.0 cm3/g or more, and a second disintegrator component other than the first disintegrator component and an excipient. The method includes a first wet granulation step using any two of the three components, and a second wet granulation step using the granules obtained in the first wet granulation step and at least the component not used in the first wet granulation step; thus the disintegrative particulate composition is produced. Moreover, an orally disintegrating tablet contains a medicinal ingredient and the disintegrative particulate composition.
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5.发明申请公开(公告)号：US20180168934A1
公开(公告)日：2018-06-21
申请号：US15737939
申请日：2016-06-28
申请人： DAICEL CORPORATION
CPC分类号： A61J3/10 , A61J3/005 , A61J3/06 , A61K9/2826 , A61K9/286 , A61K9/2866 , A61K9/2893 , B30B11/34
摘要： The purpose of present invention to provide a method for the production of an easy-to-take solid preparation, which is mainly characterized in that a coating processing for the easy-to-take property is simply performed by using a gelling agent in a dry process, without going through a wet condition, the easy-to-take solid preparation and the like.The present invention relates to a dry-process method for the production of an easy-to-take solid preparation wherein a compression-molded core is coated with a coating agent comprising a gelling agent that will show slipperiness when it is brought into contact with water, comprising directly applying only powder of the coating agent to a mortar inner surface, the bottom end surface of an upper-pestle, and the top end surface of a lower-pestle, and subsequently loading and integrally compression-molding a core-molding material; a powder composition for coating the solid preparation, which comprises a water-soluble polymer to be used in the aforementioned production method, and the like.
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6.发明申请INTRAORALLY DISINTEGRABLE TABLET COMPRISING DISINTEGRABLE GRANULAR COMPOSITION 审中-公开包含消毒性颗粒组合物的真菌消毒片公开(公告)号：US20160213619A1
公开(公告)日：2016-07-28
申请号：US14915872
申请日：2014-09-24
申请人： DAICEL CORPORATION
发明人： Takahiro HIRAMURA , Kiyoshi IKURA , Sae ITAYA , Tomohito OKABAYASHI , Anan SAKAGUCHI , Tetsuro MORITA , Kimiko IKEDA
IPC分类号： A61K9/20 , A61K31/4174 , A61K31/192 , A61K31/198 , A61K31/167 , A61K31/426 , A61K31/375 , A61K9/00 , A61K31/166
CPC分类号： A61K9/2095 , A61K9/0056 , A61K9/2013 , A61K9/2027 , A61K9/2054 , A61K9/2077 , A61K31/166 , A61K31/167 , A61K31/192 , A61K31/198 , A61K31/375 , A61K31/4174 , A61K31/426
摘要： An object of the present invention is to provide an orally disintegrating tablet having both an excellent tablet hardness and disintegrability even when the content of a medicinal ingredient is high.This invention relates to an orally disintegrating tablet comprising a medicinal ingredient having distribution coefficient (log P) in a range of from −6.0 to 10.0 and a disintegrative particulate composition produced by granulation consisting of at least two stages, especially to said orally disintegrating tablet having tablet hardness of from 30 to 100 N, and disintegration time in water of from 10 to 30 sec.
摘要翻译： 本发明的目的是提供即使当药物成分高时也具有优异的片剂硬度和崩解性的口腔崩解片剂。 本发明涉及一种口腔崩解片，其包含分布系数（logP）在-6.0〜10.0范围内的药用成分，以及由至少两个阶段组成的造粒产生的崩解性颗粒组合物，特别是所述口腔崩解片剂， 片剂硬度为30〜100N，水分解时间为10〜30秒。
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公开(公告)号：US20160136097A1
公开(公告)日：2016-05-19
申请号：US14898423
申请日：2014-07-04
申请人： DAICEL CORPORATION
IPC分类号： A61K9/20
CPC分类号： A61K9/2054 , A61K9/0056 , A61K9/1652 , A61K9/2009 , A61K9/2095
摘要： An object of the present invention is to provide an orally disintegrating tablet (ultrafast-disintegrating tablet) having an extremely high disintegrability (short disintegration time), and a high tablet hardness, and to provide a simple method for the production of said ultrafast-disintegrating tablet without such a complicated process as freeze-drying.This invention relates to an orally disintegrating tablet comprising a first disintegrator component of an acid-type carboxymethylcellulose, and having a tablet hardness of 10 N or more and a disintegration time in water of less than 15 seconds, a method for the production of said orally disintegrating tablet, and to a disintegrative particulate composition for use in said method.
摘要翻译： 本发明的目的是提供一种具有极高崩解性（崩解时间短）和高片剂硬度的口腔崩解片（超快崩解片），并且提供了制备所述超快崩解剂的简单方法 片剂没有如冷冻干燥这样复杂的过程。 本发明涉及一种口腔崩解片，其包含酸型羧甲基纤维素的第一崩解剂组分，片剂硬度为10N以上，在水中的崩解时间少于15秒，口服制备方法 崩解片剂和用于所述方法的崩解微粒组合物。
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公开(公告)号：US20210290497A1
公开(公告)日：2021-09-23
申请号：US17261361
申请日：2019-07-23
申请人： Daicel Corporation
IPC分类号： A61K8/02 , A61K8/73 , A61Q19/10 , A23L23/10 , A23L29/262 , A23L29/212 , A23L29/30 , A23P10/28
摘要： The present application provides a disintegrating particulate composition containing microfibrous cellulose; a disintegrating solid containing the composition; and the like.
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公开(公告)号：US20200268650A1
公开(公告)日：2020-08-27
申请号：US16067894
申请日：2017-01-16
申请人： Daicel Corporation
摘要： The purpose of the present invention is to provide an intraoral retentive disintegrating solid preparation having excellent disintegrability and cohesiveness, a method for the production thereof, and a powder composition for use in the method for the said production.The present invention relates to an intraoral retentive disintegrating solid preparation comprising at least one kind of a disintegrator and at least one kind of a water-soluble polymer, wherein a disintegration starting time is within 40 seconds and a cohesiveness index is 0.4 or more, a method for the production thereof, and a powder composition for use in the method for the said production, etc.
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10.发明申请公开(公告)号：US20190110998A1
公开(公告)日：2019-04-18
申请号：US15760854
申请日：2016-09-21
申请人： DAICEL CORPORATION
IPC分类号： A61K9/28 , A23L29/262 , A23L29/269 , A23L29/256 , A23L33/125 , A23P10/22 , A23P10/28 , A23P20/10
摘要： An object of the present invention is to provide a particulate composition for an easy-to-take solid preparation, which has excellent moldability (hardness) and slipperiness.The present invention relates to a particulate composition for an easy-to-take solid preparation, comprising sugar alcohol and a gelling agent that will show slipperiness when it is brought into contact with water, wherein a part or whole of the surface of the particulate composition is coated with the gelling agent, to an easy-to-take solid preparation comprising the particulate composition, and to a method for the production of the easy-to-take solid preparation.
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