公开(公告)号：US20140155398A1

公开(公告)日：2014-06-05

申请号：US14088093

申请日：2013-11-22

申请人： Daiichi Sankyo Company, Limited

发明人： Ashwani Kumar Verma ,  Kumaragurubaran Nagaswamy ,  Lalima Sharma ,  Soma Ghosh ,  Balkrishna Ramchandra Kale ,  Aniruddha Mondal ,  Punit Kumar Srivastava ,  Sunanda Ghosh Dastidar ,  Rijwan Jaffer Momin ,  Pradip Balu Wagh ,  Sonali Nanasaheb Pansare ,  Pramod Raosaheb Markad ,  Yogesh Balasaheb Khairnar ,  Rie Miyauchi ,  Takeshi Murata ,  Masayuki Ishizaki ,  Masatoshi Nagamochi ,  Shin Iimura

IPC分类号： C07D471/04

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

摘要翻译： 本发明提供式（I）的杂环化合物，其药学上可接受的盐，其前药或其水合物，其中A，A'B，D，R 1，R 2和R 3如本文所定义，药物组合物包含 式（I）的化合物作为活性成分，生产方法及其使用方法。 特别地，本发明提供了可用于治疗或预防与蛋白激酶相关的疾病，病症或病症（优选Janus Kinase家族）的式（I）化合物。

公开(公告)号：US09364466B2

公开(公告)日：2016-06-14

申请号：US14622560

申请日：2015-02-13

申请人： Daiichi Sankyo Company, Limited

发明人： Ashwani Kumar Verma ,  Kumaragurubaran Nagaswamy ,  Lalima Sharma ,  Soma Ghosh ,  Balkrishna Ramchandra Kale ,  Aniruddha Mondal ,  Punit Kumar Srivastava ,  Sunanda Ghosh Dastidar ,  Rijwan Jaffer Momin ,  Pradip Balu Wagh ,  Sonali Nanasaheb Pansare ,  Pramod Raosaheb Markad ,  Yogesh Balasaheb Khairnar ,  Rie Miyauchi ,  Takeshi Murata ,  Masayuki Ishizaki ,  Masatoshi Nagamochi ,  Shin Iimura

IPC分类号： A61K31/437 ,  A61K31/4353 ,  C07D471/04 ,  A61K31/506 ,  A61K31/5377

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

公开(公告)号：US20150157613A1

公开(公告)日：2015-06-11

申请号：US14622560

申请日：2015-02-13

申请人： DAIICHI SANKYO COMPANY, LIMITED

发明人： Ashwani Kumar Verma ,  Kumaragurubaran Nagaswamy ,  Lalima Sharma ,  Soma Ghosh ,  Balkrishna Ramchandra Kale ,  Aniruddha Mondal ,  Punit Kumar Srivastava ,  Sunanda Ghosh Dastidar ,  Rijwan Jaffer Momin ,  Pradip Balu Wagh ,  Sonali Nanasaheb Pansare ,  Pramod Raosaheb Markad ,  Yogesh Balasaheb Khairnar ,  Rie Miyauchi ,  Takeshi Murata ,  Masayuki Ishizaki ,  Masatoshi Nagamochi ,  Shin Iimura

IPC分类号： A61K31/437 ,  A61K31/5377 ,  A61K31/506

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

摘要翻译： 本发明提供式（I）的杂环化合物，其药学上可接受的盐，其前药或其水合物，其中A，A'B，D，R 1，R 2和R 3如本文所定义，药物组合物包含 式（I）的化合物作为活性成分，生产方法及其使用方法。 特别地，本发明提供了可用于治疗或预防与蛋白激酶相关的疾病，病症或病症（优选Janus Kinase家族）的式（I）化合物。

公开(公告)号：US08980911B2

公开(公告)日：2015-03-17

申请号：US14088093

申请日：2013-11-22

申请人： Daiichi Sankyo Company, Limited

发明人： Ashwani Kumar Verma ,  Kumaragurubaran Nagaswamy ,  Lalima Sharma ,  Soma Ghosh ,  Balkrishna Ramchandra Kale ,  Aniruddha Mondal ,  Punit Kumar Srivastava ,  Sunanda Ghosh Dastidar ,  Rijwan Jaffer Momin ,  Pradip Balu Wagh ,  Sonali Nanasaheb Pansare ,  Pramod Raosaheb Markad ,  Yogesh Balasaheb Khairnar ,  Rie Miyauchi ,  Takeshi Murata ,  Masayuki Ishizaki ,  Masatoshi Nagamochi ,  Shin Iimura

IPC分类号： C07D401/02 ,  C07D401/10 ,  A61K31/437 ,  A61K31/4353 ,  C07D471/04

CPC分类号： A61K31/437 ,  A61K31/506 ,  A61K31/5377 ,  C07D471/04

摘要： The present invention provides a heterocyclic compound of formula (I), a pharmaceutically acceptable salt thereof, a prodrug thereof or a hydrate thereof, wherein A, A′ B, D, R1, R2 and R3 are as defined herein, a pharmaceutical composition comprising a compound of formula (I) as an active ingredient, methods of production, and methods of use thereof. Particularly, the present invention provides a compound of formula (I) useful for treating or preventing a disease, condition or disorder associated with protein kinases, preferably Janus Kinase family.

摘要翻译： 本发明提供式（I）的杂环化合物，其药学上可接受的盐，其前药或其水合物，其中A，A'B，D，R 1，R 2和R 3如本文所定义，药物组合物包含 式（I）的化合物作为活性成分，生产方法及其使用方法。 特别地，本发明提供了可用于治疗或预防与蛋白激酶相关的疾病，病症或病症（优选Janus Kinase家族）的式（I）化合物。