公开(公告)号：US20230192644A1

公开(公告)日：2023-06-22

申请号：US17926074

申请日：2021-05-20

申请人： DANA-FARBER CANCER INSTITUTE, INC.

发明人： Nathanael S. Gray ,  Eric S. Fischer ,  Alyssa Verano ,  Hu Liu ,  Tinghu Zhang ,  Lyn H. Jones ,  Eric S. Wang ,  Radoslaw Nowak ,  Jianwei Che

IPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

CPC分类号： C07D401/04 ,  C07D401/14 ,  C07D405/14

摘要： Disclosed are compounds and pharmaceutically acceptable salts, hydrates, solvates, prodrugs, stereoisomers, and tautomers thereof that may cause degradation of various proteins e.g., IKZF2 (Helios). Also disclosed are pharmaceutical compositions containing same, and methods of making and using the compounds to treat diseases and disorders associated with Helios and which may benefit from Helios degradation.