公开(公告)号：US20200079753A1

公开(公告)日：2020-03-12

申请号：US16462589

申请日：2017-11-22

Applicant: DEVELOPMENT CENTER FOR BIOTECHNOLOGY

Inventor： MANN-YAN KUO ,  YING-SHUAN LEE ,  YANN-YU LU ,  CHIA-WEI LIU ,  SELINE HSIEH ,  JU-YING YANG

IPC: C07D401/04 ,  C07D239/38 ,  C07D413/12 ,  C07D401/12 ,  C07D403/12 ,  C07D413/14 ,  A61P35/00

Abstract: The present invention provides a compound of formula (I) wherein X, Y, Z1, Z2, R1, R2, A, B, p and q are as disclosed in the specification. A pharmaceutical composition and a method for modulating the Hedgehog pathway are also provided. The present invention further provides a process for preparing the compound.