公开(公告)号：US20080269465A1

公开(公告)日：2008-10-30

申请号：US12141667

申请日：2008-06-18

申请人： DILJEET SINGH ATHWAL ,  DEREK THOMAS BROWN ,  ANDREW NEIL CHARLES WEIR ,  ANDREW GEORGE POPPLEWELL ,  ANDREW PAUL CHAPMAN ,  DAVID JOHN KING

发明人： DILJEET SINGH ATHWAL ,  DEREK THOMAS BROWN ,  ANDREW NEIL CHARLES WEIR ,  ANDREW GEORGE POPPLEWELL ,  ANDREW PAUL CHAPMAN ,  DAVID JOHN KING

IPC分类号： C07K16/24

CPC分类号： C07K16/241 ,  A61K47/6845 ,  A61K47/6875 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565

摘要： There is disclosed antibody molecules containing at least one CDR derived from a mouse monoclonal antibody having specificity for human TNFα. There is also disclosed a CDR grafted antibody wherein at least one of the CDRs is a hybrid CDR. Further disclosed are DNA sequences encoding the chains of the antibody molecules, vectors, transformed host cells and uses of the antibody molecules in the treatment of diseases mediated by TNFα.

摘要翻译： 公开了含有至少一种衍生自对人TNFα具有特异性的小鼠单克隆抗体的CDR的抗体分子。 还公开了CDR移植抗体，其中至少一个CDR是杂交CDR。 进一步公开的是编码抗体分子链，载体，转化宿主细胞的链DNA序列和抗体分子在治疗由TNFα介导的疾病中的用途。