公开(公告)号：US09822174B2

公开(公告)日：2017-11-21

申请号：US14893813

申请日：2014-05-30

申请人： DONG-A SOCIO HOLDINGS CO., LTD. ,  DONG-A ST CO., LTD

发明人： Hyounmie Doh ,  Byong Moon Kim ,  Chae Young Kim ,  Sung-Hee Lee ,  Dong-Hyeon Kim ,  Yoo-jin Kim ,  Dongsop Lee ,  Kyung Mi Han ,  Dongsup Song ,  Eun-ee Jung ,  Jinseok Lee ,  Woo Jin Seung ,  Kyusang Hwang

IPC分类号： C07K16/22 ,  A61K39/395 ,  C07K16/30 ,  A61K39/00

CPC分类号： C07K16/22 ,  A61K39/3955 ,  A61K2039/505 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2317/76

摘要： A novel anti-vascular endothelial growth factor (VEGF) antibody having a strong binding affinity for VEGF and capable of inhibiting in vivo tumor growth and a composition for the treatment of cancer, containing the same. The antibody shows a remarkable binding property to human and mouse VEGF, suppresses the proliferation and permeability of a human umbilical vein endothelial cell (HUVEC) and inhibits tumor growth, and thus can be useful as an antibody for the treatment of cancer.