公开(公告)号：US09828339B2

公开(公告)日：2017-11-28

申请号：US14909096

申请日：2014-07-17

申请人： DONG-A ST CO., LTD

发明人： Soon-Hoe Kim ,  Weon-Bin Im ,  Chong-Hwan Cho ,  Sun-Ho Choi ,  Jung-Sang Park ,  Mi-Yeon Kim ,  Sung-Hak Choi ,  Min-Jung Lee ,  Kang-Hun Cho

IPC分类号： C07D207/08

CPC分类号： C07D207/08

摘要： Provided are biphenyl derivatives having the structure of Formula 1: stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen, halogen, hydroxy, substituted or unsubstituted C1-C6 alkyl, or C1-C6 alkoxy; R2, R3 and R4 are each independently hydrogen, halogen, substituted or unsubstituted amino, nitro, cyano, hydroxy, substituted or unsubstituted C1-C6 alkyl, substituted or unsubstituted C1-C6 alkoxy, or —C(O)R6; R5 is hydrogen or C1-C6 alkyl; n is 0 or 1; and R6 is hydrogen or amino, methods for preparing the same, and a pharmaceutical composition containing the same. The biphenyl derivatives having the structure of Formula 1 act as muscarinic M3 receptor antagonists, and thus are useful for the prevention or treatment of a disease selected from among chronic obstructive pulmonary disease, asthma, irritable bowel syndrome, urinary incontinence, rhinitis, spasmodic colitis, chronic cystitis, Alzheimer's disease, senile dementia, glaucoma, schizophrenia, gastroesophageal reflux disease, cardiac arrhythmia, and hyper-salivation syndromes.