公开(公告)号：US20230220035A1

公开(公告)日：2023-07-13

申请号：US17997252

申请日：2021-04-15

申请人： DONG-A ST CO., LTD.

发明人： Jae-Sung YANG ,  Kyung-Seok LEE ,  Yu-Na CHAE ,  Tae-Hyoung KIM ,  Ill-Hun JUNG ,  Chae-Lim RYU ,  Dae-Young LEE

IPC分类号： C07K14/605 ,  A61P3/04 ,  A61P3/10

CPC分类号： C07K14/605 ,  A61P3/04 ,  A61P3/10 ,  A61K38/00

摘要： A novel long-acting acylated oxyntomodulin peptide analogue having dual agonism on GLP-1 and glucagon receptors (dual GLP-1R/GlucagonR agonism) and a pharmaceutical composition including the same are disclosed. The novel long-acting acylated oxyntomodulin peptide analogue and the composition are useful for the prevention and treatment of obesity and overweight, or non-insulin-dependent diabetes accompanied by obesity and overweight. The acylated oxyntomodulin peptide analog has dual agonism for GLP-1/glucagon receptors and has an excellent increased in vivo half-life, and the pharmaceutical composition containing the same is useful for the treatment of metabolic diseases such as obesity and diabetes.

公开(公告)号：US20220119473A1

公开(公告)日：2022-04-21

申请号：US17410697

申请日：2021-08-24

申请人： DONG-A ST CO., LTD.

发明人： Jae-Sung YANG ,  Kyung-Seok LEE ,  Yu-Na CHAE ,  Gye-Rim BAEK ,  Tae-Hyoung KIM ,  Ill-Hun JUNG ,  Chae-Lim RYU ,  Weon-Bin IM

IPC分类号： C07K14/575 ,  A61P3/04 ,  A61P3/10

摘要： A novel peptide analog of acylated oxyntomodulin and its uses are disclosed. A pharmaceutical composition containing the novel peptide analog is useful and effective for preventing and treating obesity or overweightness, or diabetes accompanied by obesity and overweightness. The peptide analog and a composition containing the peptide analog are superior to those of wild-type oxyntomodulin in dual agonism on GLP-1 and glucagon receptors and longer in vivo half-life. A pharmaceutical composition containing the peptide analog is effective in the treatment of metabolic diseases such as obesity and diabetes mellitus.