公开(公告)号：US11466231B2

公开(公告)日：2022-10-11

申请号：US16972153

申请日：2019-06-04

Applicant: DSM IP Assets B.V.

Inventor： Jaroslav A. Kralovec ,  Paul Frederick Mugford ,  Alfred Rolle

IPC: C11C3/02 ,  C07C67/02 ,  C07C69/28 ,  C11C3/06

Abstract: A method for producing diglycerides is provided. The method includes combining (i) an oil comprising at least one polyunsaturated fatty acid in the form of ethyl esters, free fatty acids, and/or combinations thereof, (ii) lipase, and (iii) glycerol in water to produce diglycerides with a high level of purity. Highly pure diglycerides obtained according to the method are also provided.

公开(公告)号：US10682334B2

公开(公告)日：2020-06-16

申请号：US16166357

申请日：2018-10-22

Applicant: DSM IP ASSETS B.V.

Inventor： Szabolcs Peter ,  Joseph Schwager ,  Weerasinghe M. Indrasena ,  Jaroslav A. Kralovec ,  Bernd Mussler

IPC: A61K31/355 ,  A61P1/16 ,  A61K31/22

Abstract: The present invention relates to the use of mixtures of vitamin E and polyunsaturated fatty acids (PUFAs) as agents for the prevention, control and/or treatment of conditions associated with excessive fat accumulation in the liver which is not caused by alcohol abuse. This includes prevention, control and/or treatment of non-alcoholic steatosis in the liver—known as non-alcoholic fatty liver disease (NAFLD)—and/or non-alcoholic steatohepatitis (NASH) in a subject in need thereof. In particular, the present invention relates to the use of such compounds comprising vitamin E acetate and DHA EE as active ingredients in the manufacture of medicaments for the prevention, control and/or treatment of conditions related to NAFLD.