公开(公告)号：US10524902B2

公开(公告)日：2020-01-07

申请号：US15857359

申请日：2017-12-28

Applicant: DSM IP Assets B.V.

Inventor： Paul Frederik Gründeman ,  Jolanda Kluin ,  Karlien Kristal Boon-Ceelen ,  Thomas König

IPC: A61F2/24

Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.

公开(公告)号：US11376123B2

公开(公告)日：2022-07-05

申请号：US16702458

申请日：2019-12-03

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Frederik Gründeman ,  Jolanda Kluin ,  Karlien Kristal Boon-Ceelen ,  Thomas König

IPC: A61F2/24

Abstract: Prosthetic valves are provided with a leaflet assembly having at least one leaflet attached to a supporting element, which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets.

公开(公告)号：US10583003B2

公开(公告)日：2020-03-10

申请号：US15309030

申请日：2015-05-06

Applicant: DSM IP Assets B.V.

Inventor： Paul Frederik Grundeman ,  Jolanda Kluin ,  Karlien Kristel Boon-Ceelen ,  Thomas König

IPC: A61F2/24

Abstract: The present relates to a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet, a supporting element, and a stent to which the leaflet and supporting element are attached, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising:—providing a woven textile structure,—forming the leaflet and the supporting element from this textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, and—forming the valve therewith, wherein the textile structure has a single layer thickness of between 40 to 150 μm and comprises yarn comprising polymeric filaments, the yarn having a linear density of less than 120 dtex and an elongation at break of 10% or less, and wherein the leaflet is attached to the stent by making stitches through at least 2 layers of the woven textile structure to form a commissure. The woven fabric used method is thin and flexible, and allows stitching through multiple layers to result in durable performance of both leaflets and commissures in actual use. The invention also relates to a prosthetic valve as obtainable by said method.

公开(公告)号：US10039640B2

公开(公告)日：2018-08-07

申请号：US15308981

申请日：2015-05-06

Applicant: DSM IP Assets B.V.

Inventor： Paul Frederik Grundeman ,  Jolanda Kluin ,  Karlien Kristel Boon-Ceelen ,  Thomas König

IPC: A61F2/24

Abstract: The invention relates to a prosthetic valve comprising a leaflet assembly having at least one leaflet (3) attached to a supporting element (2), which leaflet has a free margin that can move between a first position wherein the free margin is flexed away from a closure surface (700) to allow body fluid to flow through the valve, and a second position wherein the free margin abuts the closure surface to close the valve, and wherein the leaflet, without pulsatile load on the valve, can form a coaptation height H of more than 0.1 mm along the length of the free margin. Such prosthetic valve provides good performance during prolonged time, and can be made using various materials for the leaflets. The invention also relates to a leaflet assembly for use in a prosthetic valve, and to methods of making the prosthetic valve, including making the leaflet assembly.

公开(公告)号：US11266498B2

公开(公告)日：2022-03-08

申请号：US16548752

申请日：2019-08-22

Applicant: DSM IP ASSETS B.V.

Inventor： Paul Frederik Grundeman ,  Jolanda Kluin ,  Karlien Kristel Boon-Ceelen ,  Thomas König

IPC: A61F2/24

Abstract: The present invention provides a method of making a leaflet assembly, the leaflet assembly thus made and a prosthetic valve. The leaflet assembly can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner layer forms the leaflet and the outer layer forms the supporting element. With this method a prosthetic valve can be made with little process variability and errors, and resulting in a valve with high reliability and durability.

公开(公告)号：US10441414B2

公开(公告)日：2019-10-15

申请号：US15309003

申请日：2015-05-06

Applicant: DSM IP Assets B.V.

Inventor： Paul Frederik Grundeman ,  Jolanda Kluin ,  Karlien Kristel Boon-Ceelen ,  Thomas König

IPC: A61F2/82 ,  A61F2/24

Abstract: The present invention provides a method of making a prosthetic valve that can take a first form wherein the valve is open and a second form wherein the valve is closed, the valve comprising a leaflet assembly having at least one leaflet attached to a supporting element, the leaflet having a free margin that can move between a first position wherein the valve takes the first form and a second position wherein the valve takes the second form, the method comprising providing a textile structure, and forming the leaflet assembly from the textile structure, such that a selvedge of the textile structure forms the free margin of the leaflet, wherein the textile structure is made by weaving warp and fill threads into a two-layer woven fabric having two stacked and interconnected layers, the two layers having selvedges at one longitudinal edge, and wherein forming the leaflet assembly comprises connecting two lateral edges of a single piece of the fabric to make a substantially tubular structure wherein the inner layer forms the leaflet and the outer layer forms the supporting element. With this method a prosthetic valve can be made with little process variability and errors, and resulting in a valve with high reliability and durability. The invention also relates to a method of making a leaflet assembly, and to a leaflet assembly and a prosthetic valve obtainable by said methods.