公开(公告)号：US20200087819A1

公开(公告)日：2020-03-19

申请号：US16689569

申请日：2019-11-20

Applicant: DSM IP Assets B.V.

Inventor： Mirian Hendrika Jacoba GILLISSEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

IPC: D01F6/82 ,  C08G69/44 ,  A61K9/70 ,  C08L77/12 ,  A61K9/00 ,  A61K47/34

Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (iv), wherein −m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9, −m+p+q=1 whereby m or p could be 0, −n is about 5 to about 300; (pref. 50-200), -Ri in independently selected from the group consisting of (C2-C20) alkykene or (C2-C20) alkenylene and combinations thereof; —R and R in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, ()alkyl, ()alkenyl, (C-C)alkynyl, (C-Cio)aryl, —(CH2)SH, —(CH2)2S(CH), —CH2OH, —CH(OH)CH, —(CH2)NH3, —(CH2)NHC(—NH2—)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH—CH2—CH(CH), (CH)2—CH—CH2—, H2N—(CH2), Ph-CH2—, CH—C—CH2—, HO-p-Ph-CH2—, (CH)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—; —R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol, —R is selected from bicyclic-fragments of 1,4,3,6-dianhydrohexitols of structural formula (III); —R is selected from the group consisting of (C6-Cio)aryl, (GCeJalkyl, —R is —(CH2)4—; whereby a is at least 0.05 and b is at least 0.05 and a+b−.

公开(公告)号：US20220396698A1

公开(公告)日：2022-12-15

申请号：US17774279

申请日：2020-11-12

Applicant: DSM IP Assets B.V.

Inventor： Gueorgui MIHOV

IPC: C08L77/12 ,  A61K47/34 ,  A61K9/00 ,  A61K31/5575

Abstract: Disclosed herein are polyesteramide random copolymers having high glass transition temperatures, methods of forming such polymers, devices, formulations, and medical devices containing such polymers, and methods of treating mammals suffering from various conditions using such polymers in combination with a bioactive agent. In an embodiment, the random copolymers may have a Tg above body temperature, about 37° C., and may achieve a longer release duration, different release kinetics, improved barrier properties, or other benefits over polymers with Tg below 37° C.

公开(公告)号：US20240150940A1

公开(公告)日：2024-05-09

申请号：US18391727

申请日：2023-12-21

Applicant: DSM IP Assets B.V.

Inventor： Mirian Hendrika Jacoba GILLISEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

IPC: D01F6/82 ,  A61K9/00 ,  A61K9/70 ,  A61K47/34 ,  C08G69/44 ,  C08L77/12

CPC classification number: D01F6/82 ,  A61K9/0048 ,  A61K9/70 ,  A61K47/34 ,  C08G69/44 ,  C08L77/12

Abstract: The present invention relates to fibers comprising polyesteramide co-polymers and a bioactive agent. The present invention also relates to the fibers for use in medical applications especially for use in the delivery of bioactive agents. In an embodiment, a fiber degrades hydrolytically at physiological conditions via bulk erosion.

公开(公告)号：US20220002912A1

公开(公告)日：2022-01-06

申请号：US17381320

申请日：2021-07-21

Applicant: DSM IP Assets B.V.

Inventor： Mirian Hendrika Jacoba GILLISEN-VAN DER VIGHT ,  Jens Christoph THIES ,  Gueorgui MIHOV

IPC: D01F6/82 ,  A61K9/00 ,  C08G69/44 ,  A61K47/34 ,  A61K9/70 ,  C08L77/12

Abstract: The present invention relates to fibers comprising a polyesteramide (PEA) having a chemical formula described by structural formula (IV), wherein m+p varies from 0.9-0.1 and q varies from 0.1 to 0.9; m+p+q=1 whereby m or p could be 0; n is about 5 to about 300; (pref. 50-200); R1 is independently selected from the group consisting of (C2-C20) alkylene, (C2-C20) alkenylene, —(R9—CO—O—R10—O—CO—R9)—, —CHR11—O—CO—R12—COOCR11—, and combinations thereof; R3 and R4 in a single backbone unit m or p, respectively, are independently selected from the group consisting of hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, (C1-C6)alkyl, —(CH2)SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(═NH2+)NH2, —CH2COOH, —(CH2)COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2H2COOH, CH3—CH2—CH(CH3)—, (CH3)2—CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH═C—CH2—, HO-p-Ph-CH2—, (CH3)2—CH—, Ph-NH—, NH—(CH2)3—C—, NH—CH═N—CH═C—CH2—; R5 is selected from the group consisting of (C2-C20)alkylene, (C2-C20)alkenylene, alkyloxy or oligoethyleneglycol; R6 is selected from bicyclic-fragments of 1,4:3,6-dianhydrohexitols of structural formula (III); R7 is selected from the group consisting of (C6-C10)aryl(C1-C6)alkyl; R8 is —(CH2)4-; R9 or R10 are independently selected from C2-C12 alkylene or C2-C12 alkenylene; and R11 or R12 are independently selected from H, methyl, C2-C12 alkylene or C2-C12 alkenylene whereby a is at least 0.05 and b is at least 0.05 and a+b=1.