公开(公告)号：US20140011948A1

公开(公告)日：2014-01-09

申请号：US14022977

申请日：2013-09-10

Applicant: DSM IP ASSETS B.V.

Inventor： Edwin CURRIE ,  Jens THIES ,  Paul HOLMES

IPC: C09D1/00

CPC classification number: C09D1/00 ,  C08K3/22 ,  C08K9/08 ,  C08L51/10 ,  C09D7/62 ,  Y10T428/2982

Abstract: A process for producing a coating composition includes separately chemically grafting particles with compounds having reactive groups and compounds having hydrophilic polymer chains. The hydrophilic polymer chains dissolve in water at at least one temperature between 0 and 100° C. The reactive groups may react with the substrate and or react with one another to form a cross-linked coating, comprising the particles. A process for forming a coating on a substrate is also provided.

Abstract translation: 制备涂料组合物的方法包括用具有反应性基团的化合物和具有亲水性聚合物链的化合物单独化学接枝颗粒。 亲水性聚合物链在0至100℃之间的至少一个温度下溶于水。反应性基团可与基底反应并彼此反应以形成包含该颗粒的交联涂层。 还提供了在基材上形成涂层的方法。

公开(公告)号：US20220202851A1

公开(公告)日：2022-06-30

申请号：US17546389

申请日：2021-12-09

Applicant: DSM IP Assets B.V.

Inventor： Jens THIES ,  Detlef Olaf Alexander SCHUMANN ,  George MIHOV ,  Julien François BERARD

IPC: A61K31/785 ,  A61K31/573 ,  A61K9/00 ,  A61L27/18 ,  A61K9/16 ,  C08G69/44

Abstract: The present invention relates to a formulation sized for injection comprising a biodegradable polyesteramide co-polymer comprising at least a diol of bicyclic-1,4:3,6-dianhydrohexitol and analgesics for use in the treatment of arthritic disorders. More specific the invention relates to a formulation comprising injectable microparticle according to claim 1 wherein the polyesteramide co-polymer further comprises a diacid, a diol different from bicyclic-1,4:3,6-dianhydrohexitol and at least two different amino-acids. The formulation is used to treat pain or inflammation in a patient comprising administering to said patient a therapeutically effective amount of the formulation once or twice a year.