公开(公告)号：US20210187013A1

公开(公告)日：2021-06-24

申请号：US17144967

申请日：2021-01-08

Applicant: DUKE UNIVERSITY

Inventor： Chris M. Counter ,  Donita C. Brady ,  Michelle L. Turski ,  Dennis J. Thiele

IPC: A61K33/24 ,  A61K45/06 ,  A61K33/30 ,  A61K31/095 ,  A61K31/519 ,  A61K31/275 ,  A61K31/4523 ,  A61K31/132 ,  A61K31/4745 ,  A61K31/198 ,  A61K31/18 ,  A61K31/416

Abstract: The present disclosure provides methods of treating and/or preventing cancer in a subject comprising administering to the subject a copper-reduced diet by itself or as a supplement along with a regular diet to create a copper-reduced melieu, maintain a reduced-copper melieu, or both, thereby treating and/or preventing the development of the cancer. Methods also comprise further adding a copper chelator, MEK inhibitor, or combinations thereof.

公开(公告)号：US20150017261A1

公开(公告)日：2015-01-15

申请号：US14371871

申请日：2013-01-11

Applicant: DUKE UNIVERSITY

Inventor： Chris M. Counter ,  Donita C. Brady ,  Michelle L. L. Turski ,  Dennis J. Thiele

IPC: A61K33/24 ,  A61K45/06

CPC classification number: A61K33/24 ,  A61K31/095 ,  A61K31/132 ,  A61K31/18 ,  A61K31/198 ,  A61K31/275 ,  A61K31/416 ,  A61K31/4523 ,  A61K31/4745 ,  A61K31/519 ,  A61K33/30 ,  A61K45/06 ,  A61K2300/00

Abstract: The present disclosure provides methods of treating and/or preventing cancer in a subject comprising administering to the subject a copper-reduced diet by itself or as a supplement along with a regular diet to create a copper-reduced melieu, maintain a reduced-copper melieu, or both, thereby treating and/or preventing the development of the cancer. Methods also comprise further adding a copper chelator, MEK inhibitor, or combinations thereof.

Abstract translation: 本公开提供了治疗和/或预防受试者癌症的方法，其包括向受试者施用减少铜的饮食本身或作为补充剂与常规饮食一起以产生铜还原甜菜，维持减少铜的甜味剂 ，或两者，从而治疗和/或预防癌症的发展。 方法还包括进一步加入铜螯合剂，MEK抑制剂或其组合。