公开(公告)号：US09156883B2

公开(公告)日：2015-10-13

申请号：US13966852

申请日：2013-08-14

Applicant: DYAX CORP.

Inventor： Jinan Yu ,  M. Daniel Potter ,  Brian D. Kelley ,  Jeffrey S. Deetz ,  James E. Booth

IPC: G01N33/53 ,  C07K5/00 ,  C12N7/00 ,  C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/755

CPC classification number: C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/755

Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.

公开(公告)号：US20140221611A1

公开(公告)日：2014-08-07

申请号：US13966852

申请日：2013-08-14

Applicant: DYAX CORP.

Inventor： Jinan Yu ,  M. Daniel Potter ,  Brian D. Kelley ,  Jeffrey S. Deetz ,  James E. Booth

IPC: C07K7/06 ,  C07K14/755

CPC classification number: C07K7/06 ,  C07K7/08 ,  C07K14/00 ,  C07K14/755

Abstract: It is an object of the present invention to provide novel binding molecules for factor VIII and factor VIII-like proteins. Preferred binding molecules of the present invention exhibit not only distinct characteristics for binding of the target factor VIII polypeptides but also specific and desirable characteristics for release (elution) of the target polypeptides. Especially preferred binding molecules according to the invention are short polypeptide sequences, characterized by a stable loop structure.

Abstract translation: 本发明的目的是为因子VIII和因子VIII样蛋白提供新的结合分子。 本发明优选的结合分子不仅显示了靶因子VIII多肽的结合的明显特征，而且还显示了靶多肽的释放（洗脱）的特异性和期望特征。 根据本发明的特别优选的结合分子是短多肽序列，其特征在于稳定的环结构。