公开(公告)号：US20200046762A1

公开(公告)日：2020-02-13

申请号：US16604173

申请日：2018-04-12

申请人： Daewoong Pharmaceutical Co., Ltd. ,  Liaoning Daewoong Pharmaceutical Co., Ltd.

发明人： Ye CHANG ,  Qing Ri LI ,  Sang Ho SEOL ,  Tie LI ,  Chao TONG

IPC分类号： A61K33/12 ,  A61K9/10 ,  A61K47/36 ,  A61K47/10 ,  A61K47/26 ,  A61K47/12

摘要： The present invention relates to a suspension comprising smectite, and the suspension of the present invention comprises both a polymeric suspending agent and a low molecular suspending agent, and thus exhibits high dispersibility and sinking rate, ease of administration due to not high viscosity of a formulation, enhanced drug compliance while taking the formulation, and high preference. In addition, the suspension of the present invention enables uniform dispersion in preparation thereof, thus exhibiting ease of preparation and excellent efficiency, and accordingly, has an excellent effect on reducing a defect rate in the production of a suspension preparation.

公开(公告)号：US20210292291A1

公开(公告)日：2021-09-23

申请号：US17266844

申请日：2019-08-09

申请人： Daewoong Pharmaceutical Co., Ltd.

发明人： Qing Ri LI ,  Hee Kyoon YOON

IPC分类号： C07D307/79

摘要： A method of preparing an intermediate useful for the synthesis of a diphenylmethane derivative that can be used as an SGLT inhibitor is described. A method of synthesizing a compound of Formula 7 can address problems of existing synthesis processes requiring the synthesis of the Grignard reagent and management of related substances. In addition, the method can minimize the generation of related substances, and thus does not require reprocessing of reaction products, thereby simplifying the process. Accordingly, the production yield of a diphenylmethane derivative can be maximized.