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公开(公告)号：US11840736B2
公开(公告)日：2023-12-12
申请号：US16547434
申请日：2019-08-21
发明人： Matthias Schneider , Sabine Blum , Renee Jeanne Mendell-Harary , Daniel J. Freeman , Robert Allen Beckman , Xiaoping Jin
IPC分类号： G01N33/574 , A61K39/395 , C12Q1/6886 , C07K16/32 , C07K16/28 , A61K45/06 , A61K39/00
CPC分类号： C12Q1/6886 , A61K39/39558 , A61K45/06 , C07K16/2863 , C07K16/32 , A61K2039/505 , C07K2317/73 , C12Q2600/106 , C12Q2600/158 , G01N2333/4704
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.
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公开(公告)号：US11873344B2
公开(公告)日：2024-01-16
申请号：US16547440
申请日：2019-08-21
发明人： Matthias Schneider , Sabine Blum , Renee Jeanne Mendell-Harary , Daniel J. Freeman , Robert Allen Beckman , Xiaoping Jin , Kimio Yonesaka , Kazuhiko Nakagawa
IPC分类号： C12Q1/68 , C07K16/32 , G01N33/569 , A61K31/517 , A61K39/395 , A61K45/06 , A61N5/10 , C07K16/28 , C07K16/40 , G01N33/574 , A61K39/00
CPC分类号： C07K16/32 , A61K31/517 , A61K39/39558 , A61K45/06 , A61N5/10 , C07K16/2863 , C07K16/40 , G01N33/5695 , G01N33/57423 , A61K2039/505 , C07K2317/21 , C07K2317/76 , G01N2333/4756
摘要： The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at a protein level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at a protein level is assessed as low. The invention is also directed to methods of performing an ELISA, including sequential steps of contacting a solid surface with a plurality of solutions each comprising in turn a capture antibody, a blocking agent, a sample suspected of containing an analyte, a detection antibody and an enzyme conjugate, in which the solid surface is subjected to a wash process after each sequential step.
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