公开(公告)号：US5072007A

公开(公告)日：1991-12-10

申请号：US547132

申请日：1990-07-03

申请人： Daisuke Fukuoka ,  Takeshi Ishitoku ,  Katsuya Takahashi ,  Takashi Tashiro ,  Junichi Imuta ,  Hiroaki Tan ,  Masaharu Ishiguro ,  Noriaki Kihara ,  Teruaki Mukaiyama

发明人： Daisuke Fukuoka ,  Takeshi Ishitoku ,  Katsuya Takahashi ,  Takashi Tashiro ,  Junichi Imuta ,  Hiroaki Tan ,  Masaharu Ishiguro ,  Noriaki Kihara ,  Teruaki Mukaiyama

IPC分类号： C07D311/20

CPC分类号： C07D311/20

摘要： Process for preparing polyalkyl-2-alkoxy-7-hydroxychroman derivative of the general formula (V): ##STR1## wherein R.sup.1 denotes lower primary alkyl, R.sup.2 denotes hydrogen or lower primary alkyl and R.sup.3 denotes loweralkyl, by reacting resorcin with either an aliphatic ketone of the general formula (I): ##STR2## wherein R.sup.1 and R.sup.2 are as defined above, and an alcohol of the formula (II):R.sup.3 OH (II)wherein R.sup.3 is as defined above, in the presence of an acid catalyst, or an aliphatic ketone acetal of the general formula (III): ##STR3## wherein R.sup.1, R.sup.2 and R.sup.3 are as defined above, in the presence of an acid catalyst.

公开(公告)号：US4973703A

公开(公告)日：1990-11-27

申请号：US267379

申请日：1988-11-04

申请人： Junichi Imuta ,  Noriaki Kihara ,  Takeshi Ishitoku

发明人： Junichi Imuta ,  Noriaki Kihara ,  Takeshi Ishitoku

IPC分类号： C07D233/54 ,  C07D233/64

CPC分类号： C07D233/64

摘要： A process for the purification of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}-ethyl]guanidine, which comprises bringing a crude product of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)-methylthio}ethyl]guanidine into contact with activated carbon in water in the presence of an organic acid.

公开(公告)号：US5629254A

公开(公告)日：1997-05-13

申请号：US486642

申请日：1995-06-07

申请人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

发明人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

IPC分类号： C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F4/60 ,  C08F4/602 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/64 ,  C08F4/642 ,  C08F4/659 ,  C08F4/6592 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F210/16

CPC分类号： C08F210/16 ,  C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/61912 ,  C08F4/61927 ,  C08F4/65908 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  Y10S526/904 ,  Y10S526/943

摘要： The novel transition metal catalyst of the invention is represented by the following formula (I): ##STR1## wherein M is a zirconium or hafnium; R.sup.1 is a hydrocarbon group of 2 to 6 carbon atoms, R.sup.2 is an aryl group of 6 to 16 carbon atoms; X.sup.1 and X.sup.2 are each a halogen atom; and Y is a divalent hydrocarbon group, a divalent silicon-containing group.

摘要翻译： 本发明的新型过渡金属催化剂由下式（I）表示： R 1是2至6个碳原子的烃基，R 2是6至16个碳原子的芳基; X1和X2各自为卤素原子; Y为二价烃基，二价含硅基团。

公开(公告)号：US4894475A

公开(公告)日：1990-01-16

申请号：US138076

申请日：1987-12-28

申请人： Hiroaki Tan ,  Koji Kato ,  Junichi Imuta ,  Noriaki Kihara

发明人： Hiroaki Tan ,  Koji Kato ,  Junichi Imuta ,  Noriaki Kihara

IPC分类号： C07D233/64 ,  C07C67/00 ,  C07C313/00 ,  C07C323/44 ,  C07D233/54

CPC分类号： C07D233/64 ,  C07C323/44

摘要： Disclosed are alpha-acyloxyketone derivatives which are useful as intermediates for production of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylthio}ethyl]guanidine (common name: Cimetidine; Cimetidine applies hereinafter) and Cimetidine-related compounds which have an action of controlling secretion of gastric acid and are useful as a drug for treating gastric ulcer.

公开(公告)号：US4886910A

公开(公告)日：1989-12-12

申请号：US156658

申请日：1988-02-17

申请人： Hiroaki Tan ,  Koji Kato ,  Junichi Imuta ,  Noriaki Kihara

发明人： Hiroaki Tan ,  Koji Kato ,  Junichi Imuta ,  Noriaki Kihara

IPC分类号： C07C319/20 ,  C07C67/00 ,  C07C313/00 ,  C07C323/44 ,  C07D233/54 ,  C07D233/64

CPC分类号： C07D233/64 ,  C07C323/44

摘要： The present invention provides a cyanoguanidine derivtive which is a precursor for the synthesis of N-cyano-N'-methyl-N"-[2-{(5-methyl-1H-imidazol-4-yl)methylothio}ethyl]-guanidine (Cimetidine) or its relted compound, which has an action of controlling secretion of acid in the stomach based on the histamine H.sub.2 receptor antagonism and is valuable as a drug for treating gastric ulcer. This cyanoguanidine derivative is prepared by reacting a haloketone derivative with an ammonium salt and a lower fatty acid salt or by reacting other cyanoguanidine derivative with an ammonium salt.

公开(公告)号：US5616663A

公开(公告)日：1997-04-01

申请号：US338810

申请日：1994-11-10

申请人： Junichi Imuta ,  Daisuke Fukuoka ,  Masayasu Yoshida ,  Junji Saito ,  Terunori Fujita ,  Takashi Tashiro ,  Koji Kawaai ,  Takashi Ueda ,  Yoshihisa Kiso

发明人： Junichi Imuta ,  Daisuke Fukuoka ,  Masayasu Yoshida ,  Junji Saito ,  Terunori Fujita ,  Takashi Tashiro ,  Koji Kawaai ,  Takashi Ueda ,  Yoshihisa Kiso

IPC分类号： C08F4/655 ,  C07C17/14 ,  C07C17/26 ,  C07F17/00 ,  C08F4/60 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/622 ,  C08F4/642 ,  C08F4/645 ,  C08F10/00

CPC分类号： C07C17/14 ,  C07C17/2632 ,  C07F17/00 ,  C08F10/00 ,  C08F4/61912 ,  C08F4/61927

摘要： Disclosed is a novel transition metal compound represented by the following formula: ##STR1## wherein M is a transition metal, X is halogen or the like, R.sup.1 is a hydrocarbon group or the like, R.sup.2 is an aryl group substituted with a halogenated hydrocarbon group, and Y is a divalent silicon-containing group or the like.Also disclosed are an olefin polymerization catalyst component comprising the transition metal compound, an olefin polymerization catalyst comprising the olefin polymerization catalyst component, and a process for olefin polymerization using the olefin polymerization catalyst.An olefin polymerization catalyst component having high polymerization activity can be formed from the transition metal compound. By the use of the olefin polymerization catalyst or the process for olefin polymerization, polyolefins having a high melting point and a high molecular weight can be prepared with high polymerization activity.

摘要翻译： 公开了由下式表示的新颖的过渡金属化合物：其中M为过渡金属，X为卤素等，R 1为烃基等，R 2为被卤代烃基取代的芳基 ，Y为二价含硅基团等。 还公开了包含过渡金属化合物的烯烃聚合催化剂组分，包含烯烃聚合催化剂组分的烯烃聚合催化剂和使用烯烃聚合催化剂的烯烃聚合方法。 可以由过渡金属化合物形成具有高聚合活性的烯烃聚合催化剂组分。 通过使用烯烃聚合催化剂或烯烃聚合方法，可以制备具有高聚合活性的高熔点和高分子量的聚烯烃。

公开(公告)号：US5723640A

公开(公告)日：1998-03-03

申请号：US622592

申请日：1996-03-26

申请人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

发明人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

IPC分类号： C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F4/60 ,  C08F4/602 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/64 ,  C08F4/642 ,  C08F4/659 ,  C08F4/6592 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F210/16 ,  C07F7/08

CPC分类号： C08F210/16 ,  C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/61912 ,  C08F4/61927 ,  C08F4/65908 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  Y10S526/904 ,  Y10S526/943

摘要： The novel transition metal compound of the invention is represented by the following formula (I): ##STR1## wherein M is a transition metal; R.sup.1 is a hydrocarbon group of 2 to 6 carbon atoms, R.sup.2 is an aryl group of 6 to 16 carbon atoms; X.sup.1 and X.sup.2 are each a halogen atom or the like; and Y is a divalent hydrocarbon group, a divalent silicon-containing group or the like. An olefin polymerization catalyst component of the present invention comprises the aforementioned transition metal compound.

摘要翻译： 本发明的新型过渡金属化合物由下式（I）表示：是2至6个碳原子的烃基，R 2是6至16个碳原子的芳基; X1和X2各自为卤素原子等; Y为二价烃基，二价含硅基团等。 本发明的烯烃聚合催化剂组分包含上述过渡金属化合物。

公开(公告)号：US5859272A

公开(公告)日：1999-01-12

申请号：US788568

申请日：1997-01-24

申请人： Junichi Imuta ,  Daisuke Fukuoka ,  Masayasu Yoshida ,  Junji Saito ,  Terunori Fujita ,  Takashi Tashiro ,  Koji Kawaai ,  Takashi Ueda ,  Yoshihisa Kiso

发明人： Junichi Imuta ,  Daisuke Fukuoka ,  Masayasu Yoshida ,  Junji Saito ,  Terunori Fujita ,  Takashi Tashiro ,  Koji Kawaai ,  Takashi Ueda ,  Yoshihisa Kiso

IPC分类号： C08F4/655 ,  C07C17/14 ,  C07C17/26 ,  C07F17/00 ,  C08F4/60 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/622 ,  C08F4/642 ,  C08F4/645 ,  C08F10/00 ,  C07F7/24 ,  C07F9/00

CPC分类号： C07C17/14 ,  C07C17/2632 ,  C07F17/00 ,  C08F10/00 ,  C08F4/61912 ,  C08F4/61927

摘要： Disclosed is a novel transition metal compound represented by the following formula: ##STR1## wherein M is a transition metal, X is halogen or the like, R.sup.1 is a hydrocarbon group or the like, R.sup.2 is an aryl group substituted with a halogenated hydrocarbon group, and Y is a divalent silicon-containing group or the like.Also disclosed are an olefin polymerization catalyst component comprising the transition metal compound, an olefin polymerization catalyst comprising the olefin polymerization catalyst component, and a process for olefin polymerization using the olefin polymerization catalyst.An olefin polymerization catalyst component having high polymerization activity can be formed from the transition metal compound. By the use of the olefin polymerization catalyst or the process for olefin polymerization, polyolefins having a high melting point and a high molecular weight can be prepared with high polymerization activity.

摘要翻译： 公开了由下式表示的新颖的过渡金属化合物：其中M为过渡金属，X为卤素等，R 1为烃基等，R 2为被卤代烃基取代的芳基 ，Y为二价含硅基团等。 还公开了包含过渡金属化合物的烯烃聚合催化剂组分，包含烯烃聚合催化剂组分的烯烃聚合催化剂和使用烯烃聚合催化剂的烯烃聚合方法。 可以由过渡金属化合物形成具有高聚合活性的烯烃聚合催化剂组分。 通过使用烯烃聚合催化剂或烯烃聚合方法，可以制备具有高聚合活性的高熔点和高分子量的聚烯烃。

公开(公告)号：US5658997A

公开(公告)日：1997-08-19

申请号：US474658

申请日：1995-06-07

申请人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

发明人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

IPC分类号： C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F4/60 ,  C08F4/602 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/64 ,  C08F4/642 ,  C08F4/659 ,  C08F4/6592 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F210/16

CPC分类号： C08F210/16 ,  C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/61912 ,  C08F4/61927 ,  C08F4/65908 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  Y10S526/904 ,  Y10S526/943

摘要： The novel transition metal compound of the invention is represented by the following formula (I): ##STR1## wherein M is a transition metal; R.sup.1 is a hydrocarbon group of 2 to 6 carbon atoms, R.sup.2 is an aryl group of 6 to 16 carbon atoms; X.sup.1 and X.sup.2 are each a halogen atom or the like; and Y is a divalent hydrocarbon group, a divalent silicon-containing group or the like. An olefin polymerization catalyst component of the present invention comprises the aforementioned transition metal compound. An olefin polymerization catalyst of the present invention comprises the aforementioned olefin polymerization catalyst component. The propylene homopolymer, the propylene copolymer and the propylene elastomer according to the present invention have such properties that the triad tacticity of propylene units chain is high, a proportion of the inversely units based on the 2,1-insertion of propylene monomer is in the specific range, and the intrinsic viscosity [.eta.], as measured in decahydronaphthalene at 135.degree. C., is in the specific range.

摘要翻译： 本发明的新型过渡金属化合物由下式（I）表示：是2至6个碳原子的烃基，R 2是6至16个碳原子的芳基; X1和X2各自为卤素原子等; Y为二价烃基，二价含硅基团等。 本发明的烯烃聚合催化剂组分包含上述过渡金属化合物。 本发明的烯烃聚合催化剂包含上述烯烃聚合催化剂组分。 根据本发明的丙烯均聚物，丙烯共聚物和丙烯弹性体具有丙烯单元链的三单元组立构规整度高的性质，基于丙烯单体的2,1-插入的反单元的比例在 特定范围，在十氢萘中在135℃下测定的特性粘度η在特定范围内。

公开(公告)号：US5710223A

公开(公告)日：1998-01-20

申请号：US719540

申请日：1996-09-25

申请人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

发明人： Daisuke Fukuoka ,  Takashi Tashiro ,  Koji Kawaai ,  Junji Saito ,  Takashi Ueda ,  Yoshihisa Kiso ,  Junichi Imuta ,  Terunori Fujita ,  Masatoshi Nitabaru ,  Masayasu Yoshida

IPC分类号： C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F4/60 ,  C08F4/602 ,  C08F4/619 ,  C08F4/6192 ,  C08F4/64 ,  C08F4/642 ,  C08F4/659 ,  C08F4/6592 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F210/16

CPC分类号： C08F210/16 ,  C07C45/46 ,  C07C49/67 ,  C07C49/697 ,  C07F17/00 ,  C08F10/00 ,  C08F10/06 ,  C08F110/06 ,  C08F210/06 ,  C08F4/61912 ,  C08F4/61927 ,  C08F4/65908 ,  C08F4/65912 ,  C08F4/65916 ,  C08F4/65927 ,  Y10S526/904 ,  Y10S526/943

摘要： A process for polymerizing propylene utilizes a metallocene catalyst component of the formula (I) ##STR1## wherein M is a transition metal, R.sup.1 is a C.sub.2-6 hydrocarbon, R.sup.2 is a C.sub.6-16 aryl group, X.sup.1 and X.sup.2 are each a halogen atom and Y is a divalent hydrocarbon or a divalent silicon-containing group. Propylene polymers produced thereby have such properties that the triad tacticity of propylene units is high, the proportion of inversely inserted units based on the 2,1-insertion of propylene monomer is in a specific range and the intrinsic viscosity (.eta.), as measured in decahydronaphthalene at 135.degree. C., is in a specific range.

摘要翻译： 聚合丙烯的方法使用式（I）的茂金属催化剂组分是C 2-6烃，R 2是C 6-16芳基，X 1和X 2各自是卤素原子，Y是二价烃或二价硅 包含组。 所生产的丙烯聚合物具有丙烯单元的三单元立构规整度高的性质，基于丙烯单体的2,1-插入的反向插入单元的比例在特定范围内，特性粘度（η）如 十氢萘在135℃处于特定范围内。