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    Novel Diazabicycloalkane Derivatives and Their Medical Use
    2.
    发明申请
    Novel Diazabicycloalkane Derivatives and Their Medical Use 审中-公开
    新型二氮杂双环烷烃衍生物及其医疗用途

    公开(公告)号：US20090075983A1

    公开(公告)日：2009-03-19

    申请号：US12087598

    申请日：2007-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Jeppe Kejser Christensen ,  Tino Dyhring

    IPC分类号： A61K31/4995 ,  C07D487/08 ,  A61K31/551 ,  A61P25/00 ,  A61P29/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel diaza-bicyclo-alkane derivatives, which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环烷烃衍生物，其被发现是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands
    3.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives useful as nicotinic acetylcholine receptor ligands 失效
    可用作烟碱乙酰胆碱受体配体的1,4-二氮杂双环[3.2.2]壬基杂芳基衍生物

    公开(公告)号：US07935695B2

    公开(公告)日：2011-05-03

    申请号：US12733168

    申请日：2008-08-14

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen

    IPC分类号： A61K31/55 ,  C07D243/00 ,  C07D487/22 ,  C07D491/00 ,  C07D498/00

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl heteroaryl derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基杂芳基衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Novel Diazabicyclic Aryl Derivatives and Their Medical Use
    4.
    发明申请
    Novel Diazabicyclic Aryl Derivatives and Their Medical Use 失效
    新型二氮杂环芳基衍生物及其医疗用途

    公开(公告)号：US20080161314A1

    公开(公告)日：2008-07-03

    申请号：US11884345

    申请日：2006-02-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring

    IPC分类号： A61K31/4995 ,  C07D487/08 ,  A61P25/28

    CPC分类号： C07D487/08

    摘要： This invention relates to novel diazabicyclic aryl derivatives which are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的二氮杂双环芳基衍生物，其在烟碱乙酰胆碱受体和单胺受体和转运蛋白的调节剂中被发现是胆碱能配体。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use
    5.
    发明授权
    1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their medical use 有权
    1,4-二氮杂双环[3.2.2]壬基嘧啶衍生物及其医疗用途

    公开(公告)号：US08343960B2

    公开(公告)日：2013-01-01

    申请号：US12742627

    申请日：2008-11-13

    申请人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  John Paul Redrobe ,  Jens Damsgaard Mikkelsen

    发明人： Dan Peters ,  Daniel B. Timmermann ,  Elsebet Ostergaard Nielsen ,  Gunnar M. Olsen ,  Tino Dyhring ,  Jeppe Kejser Christensen ,  John Paul Redrobe ,  Jens Damsgaard Mikkelsen

    IPC分类号： A61P25/00 ,  A61K31/55 ,  C07D471/08

    CPC分类号： C07D471/08

    摘要： This invention relates to novel 1,4-diaza-bicyclo[3.2.2]nonyl pyrimidine derivatives and their use in the manufacture of pharmaceutical compositions. The compounds of the invention are found to be cholinergic ligands at the nicotinic acetylcholine receptors and modulators of the monoamine receptors and transporters.Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the termination of abuse of chemical substances.

    摘要翻译： 本发明涉及新的1,4-二氮杂 - 双环[3.2.2]壬基嘧啶衍生物及其在制备药物组合物中的用途。 发现本发明的化合物是烟碱乙酰胆碱受体的胆碱能配体和单胺受体和转运蛋白的调节剂。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或病症，与神经变性相关的疾病或病症，与由化学物质的滥用终止引起的炎症，疼痛和戒断症状相关的疾病或病症。

    Dimeric Azacyclic Compounds and Their Use
    8.
    发明申请
    Dimeric Azacyclic Compounds and Their Use 失效
    二甲基偶氮化合物及其用途

    公开(公告)号：US20080242668A1

    公开(公告)日：2008-10-02

    申请号：US10586838

    申请日：2005-02-01

    申请人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    发明人： Dan Peters ,  Gunnar M. Olsen ,  Elsebet Ostergaard Nielsen ,  Tino Dyhring Jorgensen ,  Daniel B. Timmermann

    IPC分类号： A61K31/498 ,  C07D221/02 ,  A61K31/4375 ,  A61P9/00 ,  A61P29/00 ,  A61P25/00 ,  C07D403/02

    摘要： This invention relates to azacyclic derivatives according of formula (I) and their use as pharmaceuticals. Due to their pharmacological profile the compounds of the invention may be useful for the treatment of diseases or disorders as diverse as those related to the cholinergic system of the central nervous system (CNS), the peripheral nervous system (PNS), diseases or disorders related to smooth muscle contraction, endocrine diseases or disorders, diseases or. disorders related to neuro-degeneration, diseases or disorders related to inflammation, pain, and withdrawal symptoms caused by the′ termination of abuse of chemical substances. Formula (I) Aza-X′-A′-Y′-L-Y-A″-X″-Aza Aza:Azabicyclic group A′,A″:Aromatic monocyclic and/or polycyclic, carbocyclic and/or heterocyclic group Y′,Y″: Linker or absent (covalent bond) L: Monocyclic or polycyclic, carbocyclic or heterocyclic group or is absent X′,X″: Linker or absent (covalent bond)

    摘要翻译： 本发明涉及式（I）的氮杂环十二烷基衍生物及其作为药物的用途。 由于其药理学特征，本发明的化合物可用于治疗与中枢神经系统（CNS），周围神经系统（PNS），疾病或病症相关的胆碱能系统相关的疾病或障碍 平滑肌肉收缩，内分泌疾病或疾病，疾病或。 与“终止化学物质的滥用”引起的与炎症，疼痛和戒断症状有关的神经变性，疾病或病症相关的疾病。 式（I）Aza-X'-A'-Y'-LY-A“-X” - 氮杂氮杂：氮杂双环基A'，A“：芳族单环和/或多环，碳环和/或杂环基 Y'，Y“：连接体或不存在（共价键）L：单环或多环，碳环或杂环基团或不存在X'，X”：连接基或不存在（共价键）