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![3-Aryloxy-8-aza-bicyclo[3.2.1]]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2009/01/29/US20090030035A1/abs.jpg.150x150.jpg)
1.发明申请3-Aryloxy-8-aza-bicyclo[3.2.1]]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效3-芳氧基-8-氮杂 - 双环[3.2.1]]辛-6-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US20090030035A1
公开(公告)日：2009-01-29
申请号：US11921844
申请日：2006-06-07
IPC分类号： A61K31/46 , C07D451/02 , A61P25/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]oct-6-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛-6-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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2.发明申请Enantiomers of 3-Heteroaryl-8H-8-Azabicyclo (3.2.1) Oct-2-Ene and their Use as Monoamine Neurotransmitter Re-Uptake Inhibitors 失效3-杂芳基-8,8-8-氮杂双环（3.2.1）十二-2-烯的对映异构体及其作为单胺神经递质重吸收抑制剂的用途公开(公告)号：US20080214820A1
公开(公告)日：2008-09-04
申请号：US11793137
申请日：2005-12-15
申请人： Dan Peters , David Tristram Brown , Borje Egestad , Eva Dam , David Spencer Jones , Brian Frostrup , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , John Paul Redrobe
发明人： Dan Peters , David Tristram Brown , Borje Egestad , Eva Dam , David Spencer Jones , Brian Frostrup , Elsebet Ostergaard Nielsen , Gunnar M. Olsen , John Paul Redrobe
IPC分类号： A61K31/46 , C07D221/22 , A61P25/26
CPC分类号： C07D451/02
摘要： This invention relates to novel enantiomers useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型对映异构体。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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3.发明授权Enantiomers of 3-heteroaryl-8H-8-azabicyclo(3.2.1)oct-2-ene and their use as monoamine neurotransmitter re-uptake inhibitors 失效3-杂芳基-8,8-8-氮杂双环（3.2.1）辛-2-烯的对映异构体及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07781456B2
公开(公告)日：2010-08-24
申请号：US11793137
申请日：2005-12-15
申请人： Dan Peters , David Tristram Brown , Börje Egestad , Sinikka Marjatta Taurio, legal representative , Eva Dam , David Spencer Jones , Brian Frøstrup , Elsebet Østergaard Nielsen , Gunnar M. Olsen , John Paul Redrobe
发明人： Dan Peters , David Tristram Brown , Börje Egestad , Eva Dam , David Spencer Jones , Brian Frøstrup , Elsebet Østergaard Nielsen , Gunnar M. Olsen , John Paul Redrobe
IPC分类号： A01N43/42 , C07D401/00 , C07D405/00 , C07D409/00 , C07D411/00 , C07D413/00 , C07D417/00 , C07D419/00
CPC分类号： C07D451/02
摘要： This invention relates to novel enantiomers useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型对映异构体。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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![3-aryloxy-8-aza-bicyclo[3.2.1]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors](/abs-image/US/2009/12/29/US07638532B2/abs.jpg.150x150.jpg)
4.发明授权3-aryloxy-8-aza-bicyclo[3.2.1]oct-6-ene derivatives and their use as monoamine neurotransmitter re-uptake inhibitors 失效3-芳氧基-8-氮杂 - 双环[3.2.1]辛-6-烯衍生物及其作为单胺神经递质再摄取抑制剂的用途公开(公告)号：US07638532B2
公开(公告)日：2009-12-29
申请号：US11921844
申请日：2006-06-07
IPC分类号： A61K31/46 , C07D451/02 , A61P25/00
CPC分类号： C07D451/06
摘要： This invention relates to novel 8-aza-bicyclo[3.2.1]oct-6-ene derivatives useful as monoamine neurotransmitter re-uptake inhibitors.In other aspects the invention relates to the use of these compounds in a method for therapy and to pharmaceutical compositions comprising the compounds of the invention.
摘要翻译： 本发明涉及可用作单胺神经递质再摄取抑制剂的新型8-氮杂 - 双环[3.2.1]辛-6-烯衍生物。 在其它方面，本发明涉及这些化合物在治疗方法中的用途以及包含本发明化合物的药物组合物。
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5.发明申请公开(公告)号：US20090233929A1
公开(公告)日：2009-09-17
申请号：US12083375
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/5377 , A61K31/44 , A61K31/415 , C07D413/02 , C07D401/00 , C07D233/02
CPC分类号： C07D233/64 , C07D233/90 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D417/06
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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6.发明申请IMIDAZOLE DERIVATIVES AND THEIR USE FOR MODULATING THE GABA ALPHA RECEPTOR COMPLEX 失效咪唑衍生物及其用于调节GABA ALPHA受体复合物的用途公开(公告)号：US20090209597A1
公开(公告)日：2009-08-20
申请号：US12089883
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/4439 , C07D233/90 , A61K31/4164 , C07D401/12 , A61P25/00
CPC分类号： C07D233/90 , C07D401/10 , C07D401/12 , C07D403/12
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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7.发明申请Imidazole Derivatives and Their Use for Modulating the Gabaa Receptor Complex 审中-公开咪唑衍生物及其用于调节Gabaa受体复合物的用途公开(公告)号：US20080312303A1
公开(公告)日：2008-12-18
申请号：US12089859
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Ostergaard Nielsen
IPC分类号： A61K31/4184 , A61P25/00 , C07D235/04
CPC分类号： C07D233/64 , C07D233/56
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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8.发明授权Imidazole derivatives and their use for modulating the GABAA receptor complex 失效咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US07858649B2
公开(公告)日：2010-12-28
申请号：US12083352
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
IPC分类号： C07D413/14 , C07D413/04 , A61K31/4245 , A61K31/4439
CPC分类号： C07D413/04 , C07D233/88 , C07D403/04 , C07D405/04 , C07D413/14 , C07D417/04
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith. The compounds of the invention are of the general formula (I) and include any of its stereoisomers, any mixture of its stereoisomers, and pharmaceutically acceptable salts thereof. The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物具有通式（I），并且包括其任何立体异构体，其立体异构体的任何混合物及其药学上可接受的盐。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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公开(公告)号：US08030339B2
公开(公告)日：2011-10-04
申请号：US12083375
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
IPC分类号： C07D417/06 , C07D417/14 , C07D409/06 , C07D409/14 , C07D405/06 , C07D405/14 , C07D401/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D233/64 , A61K31/506 , A61K31/444 , A61K31/4439 , A61K31/427 , A61K31/4178 , A61K31/4164
CPC分类号： C07D233/64 , C07D233/90 , C07D401/06 , C07D401/10 , C07D401/12 , C07D403/06 , C07D403/10 , C07D405/06 , C07D417/06
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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10.发明授权Imidazole derivatives and their use for modulating the GABAA receptor complex 失效咪唑衍生物及其用于调节GABA A受体复合物的用途公开(公告)号：US07939556B2
公开(公告)日：2011-05-10
申请号：US12089883
申请日：2006-10-12
申请人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
发明人： William Dalby Brown , Janus S. Larsen , Lene Teuber , David Tristram Brown , Philip K. Ahring , Naheed Mirza , Elsebet Østergaard Nielsen
IPC分类号： A61K31/415
CPC分类号： C07D233/90 , C07D401/10 , C07D401/12 , C07D403/12
摘要： This invention relates to novel imidazole derivatives, pharmaceutical compositions containing these compounds, and methods of treatment therewith.The compounds of the invention are useful in the treatment of central nervous system diseases and disorders, which are responsive to modulation of the GABAA receptor complex, and in particular for combating anxiety and related diseases.
摘要翻译： 本发明涉及新颖的咪唑衍生物，含有这些化合物的药物组合物及其处理方法。 本发明的化合物可用于治疗中枢神经系统疾病和病症，其对GABA A受体复合物的调节有反应，特别是用于对抗焦虑和相关疾病。
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