公开(公告)号：US4101677A

公开(公告)日：1978-07-18

申请号：US806790

申请日：1977-06-15

申请人： Daniel Ambrose Dunnigan ,  Adolph Oscar Geiszler ,  James Brooks Holland

发明人： Daniel Ambrose Dunnigan ,  Adolph Oscar Geiszler ,  James Brooks Holland

IPC分类号： C07C217/74 ,  A61K31/13 ,  A61K31/135 ,  C07C67/00 ,  C07C213/00

CPC分类号： C07C2102/10 ,  Y10S514/817

摘要： Covers a compound selected from the group consisting of a member of the formula: ##STR1## wherein R.sub.1 is a radial selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R.sub.1 radical contains at least six carbon atoms, R.sub.2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R.sub.2 radical contains 1 - 3 carbon atoms, and R.sub.3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

摘要翻译： 包括选自下列成员组成的组的化合物：其中R1是选自由较高支链或直链烷基和环烷基组成的组的放射线，其中所述R 1基团含有至少6个碳原子，R 2 是选自氢，低级烷基和低级烷醇基团的基团，其中所述R 2基团含有1-3个碳原子，并且R 3是甲氧基; 和无毒的药学上可接受的酸加成盐。 还包括所述化合物作为局部麻醉剂的用途和包含所述上述化合物作为活性成分的药物组合物。

公开(公告)号：US4057582A

公开(公告)日：1977-11-08

申请号：US401018

申请日：1973-09-26

申请人： Daniel Ambrose Dunnigan ,  Adolph Oscar Geiszler ,  James Brooks Holland

发明人： Daniel Ambrose Dunnigan ,  Adolph Oscar Geiszler ,  James Brooks Holland

IPC分类号： C07C217/74 ,  A61K31/13 ,  A61K31/135 ,  C07C67/00 ,  C07C213/00 ,  C07C91/16

CPC分类号： C07C2102/10 ,  Y10S514/817

摘要： Covers a compound selected from the group consisting of a member of the formula: ##STR1## where R.sub.1 is a radical selected from the group consisting of higher branched or straight chain alkyl and cycloalkyl radicals wherein said R.sub.1 radical contains at least six carbon atoms, R.sub.2 is a radical selected from the group consisting of hydrogen, loweralkyl and loweralkanol radicals, wherein said R.sub.2 radical contains 1-3 carbon atoms, and R.sub.3 is methoxy; and nontoxic pharmaceutically acceptable acid addition salts thereof. Also covers the use of said compound as a local anesthetic and pharmaceutical compositions comprising said above compounds as the active ingredient.

摘要翻译： 包括选自下列成员的化合物：其中R 1是选自较高支链或直链烷基和环烷基的基团，其中所述R 1基团含有至少6个碳原子，R 2 是选自氢，低级烷基和低级烷醇基团的基团，其中所述R 2基团含有1-3个碳原子，并且R 3是甲氧基; 和无毒的药学上可接受的酸加成盐。 还包括所述化合物作为局部麻醉剂的用途和包含所述上述化合物作为活性成分的药物组合物。