公开(公告)号：US20130189363A1

公开(公告)日：2013-07-25

申请号：US13814398

申请日：2010-08-05

申请人： Daniel Obrecht ,  Frank Otto Gombert ,  John Anthony Robinson ,  Krystyna Patora-Komisarska

发明人： Daniel Obrecht ,  Frank Otto Gombert ,  John Anthony Robinson ,  Krystyna Patora-Komisarska

IPC分类号： C07K7/54

CPC分类号： C07K7/54 ,  A01N47/44 ,  C07K7/64

摘要： β-Hairpin peptidomimetics of the general formula Cyclo (-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-), enantiomers and pharmaceutically acceptable salts thereof, with Xaa1-Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have anti-infective activity, e.g. to selectively inhibit the growth of or to kill microorganisms such as Bacillus subtilis and/or Shigella boydii. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

摘要翻译： 通式为Xaa1（-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-）的β-发夹肽模拟物，其对映异构体和药学上可接受的盐， -Xaa14是在说明书和权利要求书中定义的某些类型的氨基酸残基，具有抗感染活性，例如， 选择性地抑制枯草芽孢杆菌和/或志贺氏志贺氏杆菌等生长或杀死微生物。 它们可用作治疗或预防感染的药物，或用作食品，化妆品，药​​物或其他含营养材料的消毒剂。 这些肽模拟物可以通过基于混合固相和溶液相合成策略的方法制造。

公开(公告)号：US08895499B2

公开(公告)日：2014-11-25

申请号：US13814398

申请日：2010-08-05

申请人： Daniel Obrecht ,  Frank Otto Gombert ,  John Anthony Robinson ,  Krystyna Patora-Komisarska

发明人： Daniel Obrecht ,  Frank Otto Gombert ,  John Anthony Robinson ,  Krystyna Patora-Komisarska

IPC分类号： A61K38/00 ,  C07K7/54 ,  A01N47/44 ,  C07K7/64

CPC分类号： C07K7/54 ,  A01N47/44 ,  C07K7/64

摘要： β-Hairpin peptidomimetics of the general formula Cyclo(-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-), enantiomers and pharmaceutically acceptable salts thereof, with Xaa1-Xaa14 being amino acid residues of certain types which are defined in the description and the claims, have anti-infective activity, e.g. to selectively inhibit the growth of or to kill microorganisms such as Bacillus subtilis and/or Shigella boydii. They can be used as medicaments to treat or prevent infections or as disinfectants for foodstuffs, cosmetics, medicaments or other nutrient-containing materials. These peptidomimetics can be manufactured by a process which is based on a mixed solid- and solution phase synthetic strategy.

摘要翻译： 通式为（-Xaa1-Xaa2-Xaa3-Xaa4-Xaa5-Xaa6-Xaa7-Xaa8-Xaa9-Xaa10-Xaa11-Xaa12-Xaa13-Xaa14-）的通式肽模拟物，其对映异构体和药学上可接受的盐与 作为在说明书和权利要求书中定义的某些类型的氨基酸残基的Xaa1-Xaa14具有抗感染活性，例如 选择性地抑制枯草芽孢杆菌和/或志贺氏志贺氏杆菌等生长或杀死微生物。 它们可用作治疗或预防感染的药物，或用作食品，化妆品，药​​物或其他含营养材料的消毒剂。 这些肽模拟物可以通过基于混合固相和溶液相合成策略的方法制造。