公开(公告)号：US07838518B2

公开(公告)日：2010-11-23

申请号：US10504556

申请日：2003-02-05

申请人： Daniel Spinks ,  Richard E. Armer ,  David J. Miller ,  Zoran Rankovic ,  Gayle Spinks ,  Jordi Mestres ,  David Robert Jaap

发明人： Daniel Spinks ,  Richard E. Armer ,  David J. Miller ,  Zoran Rankovic ,  Gayle Spinks ,  Jordi Mestres ,  David Robert Jaap

IPC分类号： A61K31/55 ,  C07D403/02

CPC分类号： C07D401/12 ,  C07D209/18 ,  C07D209/42 ,  C07D401/14 ,  C07D403/12

摘要： The present invention relates to 1-arylsulfonyl-3 substituted indole or indoline derivatives having the general formula (I) (I) wherein the dotted line represents an optional bond; n is 0 or 1; m is 0-5 and Ar, R6-R11 are defined in the description. The invention further relates to pharmaceutical compositions comprising said derivatives, and to the use of these 1-arylsulfonyl-3-substituted indole or indoline derivatives in the treatment of central nervous disorders such as psychosis, schizophrenia, manic depressions, depressions, neurological disorders, cognitive enhancement, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease and Huntington's disease.

摘要翻译： 本发明涉及具有通式（I）（I）的1-芳基磺酰基-3-取代的吲哚或二氢吲哚衍生物，其中虚线表示任选的键; n为0或1; m是0-5，Ar，R6-R11在说明书中定义。 本发明还涉及包含所述衍生物的药物组合物，以及这些1-芳基磺酰基-3-取代的吲哚或二氢吲哚衍生物在治疗中枢神经障碍如精神病，精神分裂症，躁狂性沮丧，沮丧，神经障碍，认知 增强，帕金森病，肌萎缩性侧索硬化，阿尔茨海默病和亨廷顿疾病。