公开(公告)号：US20220403428A1

公开(公告)日：2022-12-22

申请号：US17642815

申请日：2020-09-16

申请人： Danmarks Tekniske Universitet

发明人： Irina Borodina ,  Nicholas Milne ,  Steven van der Hoek ,  Morten Otto Alexander Sommer ,  Jérémy Christophe Daniel Armetta ,  Philip Tinggaard Thomsen

IPC分类号： C12P13/22 ,  C12N15/81

摘要： The present disclosure relates to methods for production of 4-hydroxytryptamine and derivatives thereof in a yeast cell. Herein are also disclosed methods for production of halogenated tryptophans and derivatives thereof in a cell. Herein are also disclosed methods for production of methylated tryptamine. The disclosure also provides nucleic acid constructs and cells useful for performing the present methods.