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公开(公告)号：US08092835B1
公开(公告)日：2012-01-10
申请号：US13269738
申请日：2011-10-10
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/1647 , Y10T428/2982
摘要： Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
摘要翻译： 可注射的微球体是通过将双键官能化的酯溶解在疏水性有机溶剂中，形成稳定剂的水溶液，形成稳定剂溶液形成连续相的水乳液的方法从双键官能化的多元醇酯得到的， 酯溶液构成分散相并蒸发有机溶剂或由PGCLM和甲氧基聚（乙二醇）的嵌段共聚物蒸发。
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公开(公告)号：US20110151004A1
公开(公告)日：2011-06-23
申请号：US13015193
申请日：2011-01-27
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
CPC分类号： A61K9/0019 , A61K9/1647 , Y10T428/2982
摘要： Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
摘要翻译： 可注射的微球体是通过将双键官能化的酯溶解在疏水性有机溶剂中，形成稳定剂的水溶液，形成稳定剂溶液形成连续相的水乳液的方法从双键官能化的多元醇酯得到的， 酯溶液构成分散相并蒸发有机溶剂或由PGCLM和甲氧基聚（乙二醇）的嵌段共聚物蒸发。
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公开(公告)号：US20080226725A1
公开(公告)日：2008-09-18
申请号：US12130001
申请日：2008-05-30
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US08246994B2
公开(公告)日：2012-08-21
申请号：US12130001
申请日：2008-05-30
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US08246993B2
公开(公告)日：2012-08-21
申请号：US11148641
申请日：2005-06-09
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US08034383B2
公开(公告)日：2011-10-11
申请号：US13015193
申请日：2011-01-27
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/1647 , Y10T428/2982
摘要： Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
摘要翻译： 可注射的微球体是通过将双键官能化的酯溶解在疏水性有机溶剂中，形成稳定剂的水溶液，形成稳定剂溶液形成连续相的水乳液的方法从双键官能化的多元醇酯得到的， 酯溶液构成分散相并蒸发有机溶剂或由PGCLM和甲氧基聚（乙二醇）的嵌段共聚物蒸发。
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公开(公告)号：US20060013886A1
公开(公告)日：2006-01-19
申请号：US11148662
申请日：2005-06-09
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61K9/14
CPC分类号： A61K9/0019 , A61K9/1647 , Y10T428/2982
摘要： Injectable microspheres are obtained from double bond functionalized polyhydric alcohol ester by a method comprising dissolving the double bond functionalized esters in a hydrophobic organic solvent, forming an aqueous solution of stabilizer, forming an oil in water emulsion where the solution of stabilizer constitutes the continuous phase and the solution of ester constitutes the disperse phase and evaporating the organic solvent or from block copolymer of PGCLM and methoxy poly(ethylene glycol).
摘要翻译： 可注射的微球体是通过将双键官能化的酯溶解在疏水性有机溶剂中，形成稳定剂的水溶液，形成稳定剂溶液形成连续相的水乳液的方法从双键官能化的多元醇酯得到的， 酯溶液构成分散相并蒸发有机溶剂或由PGCLM和甲氧基聚（乙二醇）的嵌段共聚物蒸发。
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公开(公告)号：US20060013856A1
公开(公告)日：2006-01-19
申请号：US11148641
申请日：2005-06-09
申请人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
发明人： Daqing Wu , Chih-Chang Chu , Joseph Carozza
IPC分类号： A61F2/00
CPC分类号： A61K39/385 , A61K47/34 , A61K2039/55516 , A61K2039/6081
摘要： New hydrogel, including a hydrogel containing cationic BSA is included in a vaccine to stimulate the immune system to increase the potency of the vaccine.
摘要翻译： 包含含有阳离子BSA的水凝胶的新水凝胶包括在疫苗中以刺激免疫系统以增加疫苗的效力。
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公开(公告)号：US20110287040A1
公开(公告)日：2011-11-24
申请号：US13113392
申请日：2011-05-23
IPC分类号： A61K39/00 , A61P11/06 , A61P31/04 , A61P37/08 , A61P19/08 , A61P25/06 , A61P17/00 , A61P37/00 , A61K38/07 , A61P1/00 , A61P17/02 , A61P17/06 , A61P5/00 , A61P19/02
CPC分类号： A61K38/07
摘要： The subject invention pertains to peptides and salts thereof that are useful as anti-inflammatory agents and to compositions containing such peptides and salts as active ingredients. Specifically exemplified herein are endomorphin-1 peptide (EM-1), analogs and salts thereof, and uses for modulation of calcitonin gene-related peptide (CGRP) production and/or substance P (SP) and for treatment of inflammation, particularly neurogenic inflammation.
摘要翻译： 本发明涉及可用作抗炎剂的肽及其盐，以及含有这些肽和盐作为活性成分的组合物。 本文具体示例的是内啡肽-1（EM-1），其类似物和盐，以及用于调节降钙素基因相关肽（CGRP）产生和/或物质P（SP）和用于治疗炎症，特别是神经源性炎症的用途 。
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