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公开(公告)号：US20130053769A1
公开(公告)日：2013-02-28
申请号：US13477774
申请日：2012-05-22
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening' member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译： 提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。 导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴 通过外球囊中的孔，向身体血管施加治疗剂。 内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。 优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊充气，通过外球囊输送治疗剂并容纳导线 （50）。 导管球囊组件可以提供改善的易处理性和/或可推动性特征。
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公开(公告)号：US08182446B2
公开(公告)日：2012-05-22
申请号：US12676786
申请日：2008-09-11
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening′ member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译： 提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。 导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴 通过外球囊中的孔，向身体血管施加治疗剂。 内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。 优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊膨胀，将治疗剂输送通过外气囊并容纳导线 （50）。 导管球囊组件可以提供改善的易处理性和/或可推动性特征。
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公开(公告)号：US08784602B2
公开(公告)日：2014-07-22
申请号：US13477774
申请日：2012-05-22
IPC分类号： A61M25/00
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening' member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译： 提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。 导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴 通过外球囊中的孔，向身体血管施加治疗剂。 内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。 优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊膨胀，将治疗剂输送通过外气囊并容纳导线 （50）。 导管球囊组件可以提供改善的易处理性和/或可推动性特征。
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公开(公告)号：US20110060276A1
公开(公告)日：2011-03-10
申请号：US12676786
申请日：2008-09-11
CPC分类号： A61M25/10 , A61M25/1027 , A61M2025/0004 , A61M2025/1013 , A61M2025/105 , A61M2025/1056
摘要： Catheter balloon assemblies (10) for delivering a therapeutic agent to a body vessel are provided, as well as related methods of manufacturing and methods of treatment. The catheter balloon assemblies may include a concentrically disposed dual balloon assembly at the distal portion of the catheter having an inner balloon (44), a porous outer balloon (42) concentrically arrayed around the inner balloon and a catheter shaft (30) adapted to deliver a therapeutic agent to the body vessel through the apertures in the outer balloon. Radial outward expansion of the inner balloon may urge the outer balloon into contact with the wall of a body vessel, where the therapeutic agent may be delivered from the catheter shaft through apertures in the outer balloon directly to the wall of the body vessel. Preferably, the catheter balloon assemblies include a stiffening′ member (210) within the proximal portion and/or a plurality of lumens lined with a fluorinated hydrocarbon to independently inflate the inner balloon, deliver the therapeutic agent through the outer balloon and house a wire guide (50). The catheter balloon assemblies may provide improved tractability and/or pushability characteristics.
摘要翻译： 提供了用于将治疗剂递送至身体血管的导管气囊组件（10），以及相关的制造方法和治疗方法。 导管球囊组件可以包括在导管的远端部分处的同心设置的双球囊组件，其具有内球囊（44），围绕内球囊同心排列的多孔外球囊（42）和适于递送的导管轴 通过外球囊中的孔，向身体血管施加治疗剂。 内球囊的径向向外膨胀可以促使外球囊与体血管的壁接触，其中治疗剂可以通过外球囊中的孔直接从导管轴输送到身体血管的壁。 优选地，导管球囊组件包括近端部分内的加强构件（210）和/或内衬有氟化烃的多个内腔，以独立地使内球囊膨胀，将治疗剂输送通过外气囊并容纳导线 （50）。 导管球囊组件可以提供改善的易处理性和/或可推动性特征。
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公开(公告)号：US08764727B2
公开(公告)日：2014-07-01
申请号：US13254117
申请日：2010-03-04
CPC分类号： A61M25/005 , A61M25/0053 , A61M25/10 , A61M2025/0183
摘要： A medical balloon catheter including a shaft comprised of a cross-wound coil tube and a sleeve surrounding the cross-wound coil tube. The cross-wound coil tube includes a monofilament inner coil disposed within a monofilament outer coil. The inner and outer coils are wound in opposite pitch directions. In at least one embodiment, at least one of the inner and outer coils includes a tapered distal section having a tapered diameter. In at least another embodiment, the inner coil extends distally beyond the distal end of the outer coil, providing increased flexibility in a distal portion of the shaft. An inflation balloon is attached to the distal end of the shaft. The shaft includes an inflation lumen formed through the inner coil and a wire guide lumen formed through the distal portion of the shaft and extending through the chamber of the balloon.
摘要翻译： 一种医用气囊导管，其包括由交叉卷绕的线圈管和围绕所述交叉卷绕的线圈管的套筒组成的轴。 交叉卷绕的线圈管包括设置在单丝外线圈内的单丝内线圈。 内圈和外圈以相反的方向缠绕。 在至少一个实施例中，内部和外部线圈中的至少一个包括具有锥形直径的锥形远端部分。 在至少另一个实施例中，内部线圈向远侧延伸超出外部线圈的远端，从而在轴的远端部分提供增加的灵活性。 充气气球附着在轴的远端。 轴包括通过内部线圈形成的充气腔，以及通过轴的远侧部分形成并延伸穿过气囊的腔室的线引导腔。
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公开(公告)号：US20090270841A1
公开(公告)日：2009-10-29
申请号：US12150050
申请日：2008-04-24
CPC分类号： A61M25/0045 , A61M25/0068 , A61M31/005
摘要： A catheter arrangement comprises a central tube with a wall of porous material, a proximal portion of which is covered with a non-porous layer. A hub member at the proximal end of the catheter arrangement has a port in fluid communication via the lumen of the central tube with the region surrounding the exposed distal end of the tube.
摘要翻译： 导管装置包括具有多孔材料壁的中心管，其近端部分被无孔层覆盖。 在导管装置的近端处的毂构件具有经由中心管的内腔与包围管的暴露的远端的区域流体连通的端口。
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公开(公告)号：US20090149936A1
公开(公告)日：2009-06-11
申请号：US11950781
申请日：2007-12-05
CPC分类号： A61M25/0052 , A61F2/95 , A61M25/0054
摘要： A catheter for delivering an interventional device to a target site within the body of a patient. The catheter comprises an elongated shaft having a plurality of lumens extending longitudinally therein. The shaft has a proximal portion defining at least two lumens, an intermediate portion having fewer lumens than the proximal portion, and a distal portion configured for carrying the interventional device. The proximal and distal portions each have a greater stiffness than the stiffness of the intermediate portion. A stiffening member is incorporated into the intermediate portion of the shaft. The stiffening member is sized and positioned along the shaft in a manner such that the stiffness of the intermediate portion is increased relative to the stiffness of the proximal portion and the distal portion.
摘要翻译： 一种用于将介入装置递送到患者体内的目标部位的导管。 导管包括细长轴，其具有在其中纵向延伸的多个腔。 轴具有限定至少两个腔的近端部分，具有比近侧部分更少的腔的中间部分和构造成用于承载介入装置的远侧部分。 近端和远端各自具有比中间部分的刚度更大的刚度。 加强构件结合到轴的中间部分中。 加强构件的大小和尺寸沿着轴定位，使得中间部分的刚度相对于近端部分和远端部分的刚度增加。
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公开(公告)号：US09085097B2
公开(公告)日：2015-07-21
申请号：US12714589
申请日：2010-03-01
CPC分类号： B29C47/02 , A61M25/0012 , A61M25/0045 , A61M25/005 , A61M2025/006 , A61M2025/0062 , B29C47/0014 , B29C47/0023 , B29K2077/00 , B29L2031/7542
摘要： A reinforced catheter or sheath includes an inner tube manufactured via an extrusion process from a mixture of thermoplastic and hollow glass beads. The resultant tube exhibits an inner goose bump surface that defines a central lumen. A reinforcement, such as a braid and/or coil is attached to at least a segment of the outer surface of the inner tube. A second tube of thermoplastic is extruded over at least a portion of the reinforcement. The inner goose bump surface exhibits a net low coefficient of friction comparable to that of polytetrafluoroethylene (PTFE).
摘要翻译： 增强的导管或护套包括通过挤出工艺从热塑性和中空玻璃珠的混合物制造的内管。 所得管显示出限定中心腔的内部鹅凸起表面。 诸如编织物和/或线圈的加强件附接到内管的外表面的至少一个部分。 第二个热塑塑料管挤压在加强件的至少一部分上。 内部鹅凸起表现出与聚四氟乙烯（PTFE）相当的净低摩擦系数。
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公开(公告)号：US08657845B2
公开(公告)日：2014-02-25
申请号：US11748906
申请日：2007-05-15
IPC分类号： A61M29/00
CPC分类号： A61M25/104 , A61F2/95 , A61F2/958 , A61F2/966 , A61M25/0009 , A61M25/0023 , A61M25/005 , A61M25/0052 , A61M25/0054 , A61M25/1002 , A61M2025/0046 , A61M2025/018 , A61M2025/0183
摘要： A balloon catheter device of the present invention includes an elongate catheter shaft comprising multifilar cable tubing having a proximal portion and a distal portion. The proximal portion includes a coating that allows the shaft to provide a patent fluid passage, and a part of the distal portion inside a balloon may be uncoated or otherwise open to the balloon lumen, allowing for passage of fluid through the shaft into the balloon lumen.
摘要翻译： 本发明的气囊导管装置包括细长的导管轴，其包括具有近端部分和远端部分的多芯电缆管线。 近端部分包括允许轴提供专利流体通道的涂层，并且球囊内部的远端部分的一部分可以是未涂覆的或以其它方式打开到气囊腔，允许流体通过轴进入气囊腔 。
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公开(公告)号：US20120310209A1
公开(公告)日：2012-12-06
申请号：US13486048
申请日：2012-06-01
CPC分类号： A61M25/104 , A61M5/14 , A61M25/002 , A61M25/0102 , A61M25/0108 , A61M25/09 , A61M29/02 , A61M2025/0042 , A61M2025/1061
摘要： A method of treating lower leg ischemia includes advancing a wire guide upstream through a vascular access sheath extending into an artery, and increasing a downstream flow of blood at least in part by dilating a constriction in the artery with a treatment mechanism guided into the constriction via the wire guide. The method further includes withdrawing a catheter which is coupled with the treatment mechanism from the patient at the percutaneous entry point via sliding the catheter downstream through the vascular access sheath. A low profile balloon may be used as the treatment mechanism, and is advanced through the artery while the vascular access sheath protects the artery from irritation such that spasm of the artery is less likely to occur. Reduced risk of spasm advantageously enables retrograde access to chronic total occlusions such that multiple entry points into a patient's body are not necessary.
摘要翻译： 一种治疗小腿缺血的方法包括将导丝器向上游延伸穿过延伸到动脉中的血管通路护套，以及至少部分地通过用引导到狭窄部中的治疗机构扩张动脉中的狭窄来增加血液的下游流动 导线。 该方法还包括通过将下游的导管滑动通过血管通路鞘来抽出与经皮入口点处的患者与治疗机构联接的导管。 可以使用低调气囊作为治疗机构，并且通过动脉前进，同时血管通路护套保护动脉免受刺激，使得动脉痉挛不太可能发生。 降低痉挛的风险有利地使逆行进入慢性全部闭塞，使得不需要进入患者身体的多个入口点。
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