利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

9 条记录 (耗时 0.027 秒)

    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS
    1.
    发明申请
    TRANSDERMAL DELIVERY SYSTEMS FOR ACTIVE AGENTS 审中-公开
    活性物质的超导传递系统

    公开(公告)号：US20110245215A1

    公开(公告)日：2011-10-06

    申请号：US13106715

    申请日：2011-05-12

    申请人： Dario Norberto R. Carrara ,  Arnaud Grenier ,  Celine Besse ,  Stephen M. Simes ,  Leah M. Lehman

    发明人： Dario Norberto R. Carrara ,  Arnaud Grenier ,  Celine Besse ,  Stephen M. Simes ,  Leah M. Lehman

    IPC分类号： A61K31/568 ,  A61P5/26 ,  A61P15/00

    CPC分类号： A61K9/06 ,  A61K9/0014 ,  A61K31/216 ,  A61K31/56 ,  A61K47/10 ,  A61K47/32 ,  A61K47/38

    摘要： A formulation for transdermal or transmucosal administration of an active agent. The formulation includes an active agent and a delivery vehicle comprising a C2 to C4 alkanol, a polyalcohol, and a permeation enhancer of monoalkyl ether of diethylene glycol present in an amount sufficient to provide permeation enhancement of the active agent through dermal or mucosal surfaces. The formulation is substantially free of long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters in order to avoid undesirable odor and irritation effects caused by such compounds during use of the formulation. Also, the active agent is testosterone that is present in an amount of about 1%, the alkanol is ethanol that is present in an amount of about 46.28% to about 47.5% of the formulation; the polyalcohol is propylene glycol that is present in an amount of about 6% of the formulation; and the permeation enhancer is diethylene glycol monoethyl ether that is present in an amount of about 5% of the formulation.

    摘要翻译： 用于经皮或经粘膜施用活性剂的制剂。 该制剂包括活性剂和包含C2至C4链烷醇，多元醇和二甘醇单烷基醚的渗透促进剂的活性剂和递送载体，其量足以通过皮肤或粘膜表面提供活性剂的渗透增强。 制剂基本上不含长链脂肪醇，长链脂肪酸和长链脂肪酯，以避免在使用制剂期间由这些化合物引起的不希望的气味和刺激作用。 此外，活性剂是以约1％的量存在的睾酮，链烷醇是乙醇，其量为制剂的约46.28％至约47.5％; 多元醇是丙二醇，其存在量为制剂的约6％; 并且渗透增强剂是以制剂的约5％的量存在的二甘醇单乙醚。

    Methods of treating hot flashes with formulations for transdermal or transmucosal application
    5.
    发明授权
    Methods of treating hot flashes with formulations for transdermal or transmucosal application 有权
    用透皮或经粘膜应用的制剂治疗潮热的方法

    公开(公告)号：US08647665B2

    公开(公告)日：2014-02-11

    申请号：US13584302

    申请日：2012-08-13

    申请人： Stephen M. Simes ,  Leah M. Lehman

    发明人： Stephen M. Simes ,  Leah M. Lehman

    IPC分类号： A61K39/00 ,  A61K31/56

    CPC分类号： A61K9/06 ,  A61K31/565 ,  A61K47/08 ,  A61K47/10

    摘要： The present invention relates generally to methods for treating hot flashes by administering formulations for transdermal or transmucosal administration of estrogen. The formulations of the invention are effective at treating hot flashes at surprisingly low daily doses, preferably the lowest effective dose of estrogen to treat hot flashes, e.g., about 0.45 to about 0.6 mg of estrogen per day. The amount of estrogen which is administered produces an estimated nominal daily estrogen dose in a subject undergoing treatment of from about 10 to about 15 micrograms, and a serum estradiol level of between about 25 pg/ml to about 50 pg/ml. The preferred formulations are substantially free of malodorous, and irritation causing long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

    摘要翻译： 本发明一般涉及通过施用用于透皮或经粘膜施用雌激素的制剂来治疗潮热的方法。 本发明的制剂在以令人惊讶的低每日剂量治疗潮热是有效的，优选地是最低有效剂量的雌激素以治疗潮热，例如每天约0.45至约0.6mg的雌激素。 施用的雌激素的量在经历约10至约15微克的治疗的受试者中产生估计的标称的每日雌激素剂量，血清雌二醇水平为约25pg / ml至约50pg / ml。 优选的制剂基本上不含恶臭，并引起长链脂肪醇，长链脂肪酸和长链脂肪酸的刺激。

    METHODS OF TREATING HOT FLASHES WITH FORMULATIONS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION
    8.
    发明申请
    METHODS OF TREATING HOT FLASHES WITH FORMULATIONS FOR TRANSDERMAL OR TRANSMUCOSAL APPLICATION 有权
    用烫伤或转移应用制剂处理烫伤的方法

    公开(公告)号：US20120308648A1

    公开(公告)日：2012-12-06

    申请号：US13584302

    申请日：2012-08-13

    申请人： Stephen M. Simes ,  Leah M. Lehman

    发明人： Stephen M. Simes ,  Leah M. Lehman

    IPC分类号： A61K31/565 ,  A61P15/00 ,  A61K9/127

    CPC分类号： A61K9/06 ,  A61K31/565 ,  A61K47/08 ,  A61K47/10

    摘要： The present invention relates generally to methods for treating hot flashes by administering formulations for transdermal or transmucosal administration of estrogen. The formulations of the invention are effective at treating hot flashes at surprisingly low daily doses, preferably the lowest effective dose of estrogen to treat hot flashes, e.g., about 0.45 to about 0.6 mg of estrogen per day. The amount of estrogen which is administered produces an estimated nominal daily estrogen dose in a subject undergoing treatment of from about 10 to about 15 micrograms, and a serum estradiol level of between about 25 pg/ml to about 50 pg/ml. The preferred formulations are substantially free of malodorous, and irritation causing long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

    摘要翻译： 本发明一般涉及通过施用用于透皮或经粘膜施用雌激素的制剂来治疗潮热的方法。 本发明的制剂在以令人惊讶的低每日剂量治疗潮热是有效的，优选地是最低有效剂量的雌激素以治疗潮热，例如每天约0.45至约0.6mg的雌激素。 施用的雌激素的量在经历约10至约15微克的治疗的受试者中产生估计的标称的每日雌激素剂量，血清雌二醇水平为约25pg / ml至约50pg / ml。 优选的制剂基本上不含恶臭，并引起长链脂肪醇，长链脂肪酸和长链脂肪酸的刺激。

    Methods of treating hot flashes with formulations for transdermal or transmucosal application
    9.
    发明授权
    Methods of treating hot flashes with formulations for transdermal or transmucosal application 有权
    用透皮或经粘膜应用的制剂治疗潮热的方法

    公开(公告)号：US08268346B2

    公开(公告)日：2012-09-18

    申请号：US11737389

    申请日：2007-04-19

    申请人： Stephen M. Simes ,  Leah M. Lehman

    发明人： Stephen M. Simes ,  Leah M. Lehman

    IPC分类号： A61K39/00 ,  A61K31/56

    CPC分类号： A61K9/06 ,  A61K31/565 ,  A61K47/08 ,  A61K47/10

    摘要： The present invention relates generally to methods for treating hot flashes by administering formulations for transdermal or transmucosal administration of estrogen. The formulations of the invention are effective at treating hot flashes at surprisingly low daily doses, preferably the lowest effective dose of estrogen to treat hot flashes, e.g., about 0.45 to about 0.6 mg of estrogen per day. The amount of estrogen which is administered produces an estimated nominal daily estrogen dose in a subject undergoing treatment of from about 10 to about 15 micrograms, and a serum estradiol level of between about 25 pg/ml to about 50 pg/ml. The preferred formulations are substantially free of malodorous, and irritation causing long-chain fatty alcohols, long-chain fatty acids, and long-chain fatty esters.

    摘要翻译： 本发明一般涉及通过施用用于透皮或经粘膜施用雌激素的制剂来治疗潮热的方法。 本发明的制剂在以令人惊讶的低每日剂量治疗潮热是有效的，优选地是最低有效剂量的雌激素以治疗潮热，例如每天约0.45至约0.6mg的雌激素。 施用的雌激素的量在经历约10至约15微克的治疗的受试者中产生估计的标称的每日雌激素剂量，血清雌二醇水平为约25pg / ml至约50pg / ml。 优选的制剂基本上不含恶臭，并引起长链脂肪醇，长链脂肪酸和长链脂肪酸的刺激。