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公开(公告)号：US20070276015A1
公开(公告)日：2007-11-29
申请号：US11822274
申请日：2007-07-03
申请人： Darko Filic , Miljenko Dumic , Aleksandar Danilovski , Bozena Klepic , Ines Fistric , Marina Oresic , Jasna Horvat Mikulcic
发明人： Darko Filic , Miljenko Dumic , Aleksandar Danilovski , Bozena Klepic , Ines Fistric , Marina Oresic , Jasna Horvat Mikulcic
CPC分类号： A61K31/44 , C07D213/53 , C07D213/71 , C07D213/74
摘要： The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.
摘要翻译： 本发明涉及托拉塞米的新晶体改性III的表征，其制备方法是通过使用托拉塞米的碱性溶液与无机或有机酸（有或没有加入晶种）将其酸化至其 用作制备托拉塞米和托拉塞米的药学上可接受的盐的晶体改性I的原料以及含有托拉塞米的这种新的结晶改性III的药物形式。
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公开(公告)号：US20060205951A1
公开(公告)日：2006-09-14
申请号：US11357109
申请日：2006-02-21
申请人： Darko Filic , Miljenko Dumic , Aleksandar Danilovski , Bozena Klepic , Ines Fistric , Marina Oresic , Jasna Horvat Mikulcic
发明人： Darko Filic , Miljenko Dumic , Aleksandar Danilovski , Bozena Klepic , Ines Fistric , Marina Oresic , Jasna Horvat Mikulcic
IPC分类号： C07D213/75
CPC分类号： A61K31/44 , C07D213/53 , C07D213/71 , C07D213/74
摘要： The present invention relates to the characterization of a new crystal modification III of torasemide, to a process for the preparation thereof by the use of controlled acidifying of alkaline solutions of torasemide with inorganic or organic acids with or without addition of a crystal seed, to its use as a raw material for the preparation of the crystal modification I of torasemide and of pharmaceutically acceptable salts of torasemide as well as to pharmaceutical forms containing this new crystal modification III of torasemide.
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