公开(公告)号：US20070077204A1

公开(公告)日：2007-04-05

申请号：US11404484

申请日：2006-04-13

申请人： Davangere Devanand ,  Matthias Tabert ,  Xinhua Liu ,  Richard Doty

发明人： Davangere Devanand ,  Matthias Tabert ,  Xinhua Liu ,  Richard Doty

IPC分类号： A61K49/00

CPC分类号： A61K49/00

摘要： The present invention provides smell tests (odor identification tests) that are shorter that UPSIT, yet has a statistical sensitivity and specificity equivalent to or better than UPSIT. The odor identification tests of the invention are based on a core set of six odorants, where the six odorants can be selected from the following group of odorants: menthol, clove, leather, strawberry, lilac, pineapple, smoke, soap, natural gas and lemon. The present invention provides odor identification tests that can: (1) discriminate between subjects who are normal and who have a neuropsychiatric condition, cognitive disease or disorder, and/or (2) predict which subjects with mild cognitive disorders will develop various neuropsychiatric conditions or cognitive diseases and disorders. In one embodiment, the test and methods of the invention can provide an early prediction or diagnosis of Alzheimer's disease that is important for patients (including patients who have mild cognitive disorders, such as MCI) and clinicians to make plans for the future and to institute early treatment.

摘要翻译： 本发明提供比UPSIT更短的气味测试（气味鉴定测试），但具有与UPSIT相当或优于UPSIT的统计灵敏度和特异性。 本发明的气味鉴别试验基于六组气味剂的核心组合，其中六种气味剂可以选自以下一组气味剂：薄荷醇，丁香，皮革，草莓，丁香，菠萝，烟，肥皂，天然气和 柠檬。 本发明提供了气味鉴别测试，其可以：（1）区分正常和具有神经精神状况，认知疾病或障碍的受试者和/或（2）预测具有轻度认知障碍的受试者将发展各种神经精神病症或 认知障碍和疾病。 在一个实施方案中，本发明的测试和方法可以提供对患者（包括具有轻度认知障碍的患者，例如MCI）和临床医师对未来进行计划和重建的阿尔茨海默氏病的早期预测或诊断 早期治疗。