公开(公告)号：US06444641B1

公开(公告)日：2002-09-03

申请号：US09530038

申请日：2000-07-07

Applicant: David Benjamin Flora

Inventor： David Benjamin Flora

IPC: A61K3800

CPC classification number: A61K38/28

Abstract: Fatty acid-acylated insulin analogs are soluble at moderately acidic pH and provide long-acting basal control of glucose levels. In such a molecule, the insulin analog portion comprises an insulin A-chain, or an analog thereof, properly cross-linked to an analog of the insulin B-chain, wherein the &egr;-amino group of a Lys residue at either positions 28 or 29 of the B-chain analog is acylated with a fatty acid. The insulin analog portion of the molecules comprises an A-chain of insulin, or an analog thereof, with an optional Arg at position 0, properly cross-linked to a B-chain analog that includes Arg at positions 31 and 32.

Abstract translation: 脂肪酸酰化的胰岛素类似物在中等酸性pH下是可溶的，并提供对葡萄糖水平的长效基础控制。 在这种分子中，胰岛素类似物部分包含与胰岛素B链的类似物正确交联的胰岛素A链或其类似物，其中任一位置28的Lys残基的ε-氨基或 29个B链类似物用脂肪酸酰化。 分子的胰岛素类似物部分包含胰岛素的A链或其类似物，其在0位具有任选的Arg，适当地与含有31位和32位的Arg的B链类似物交联。