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公开(公告)号：US07407658B2
公开(公告)日：2008-08-05
申请号：US11611779
申请日：2006-12-15
申请人： David C. Kaslow , Takafumi Tsuboi , Motomi Torii
发明人： David C. Kaslow , Takafumi Tsuboi , Motomi Torii
IPC分类号： A61K39/00 , A61K39/015
CPC分类号： A61K39/015 , C07K16/205 , Y02A50/412
摘要： The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
摘要翻译： 本发明涉及用于阻断疟原虫的间日疟原虫传播的新方法和组合物。 特别地，公开了Pvs25和Pvs28多肽，变体，包括去糖基化形式及其融合蛋白，其当被施用于易感生物体时分别在疟原虫表面上诱导针对25kD和28kD蛋白的免疫应答 间日ax z和ookinetes。 易感生物体内的这种免疫应答可以阻止疟疾传播。
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公开(公告)号：US07192934B1
公开(公告)日：2007-03-20
申请号：US09554960
申请日：1998-12-04
申请人： David C. Kaslow , Takafumi Tsuboi , Motomi Torii
发明人： David C. Kaslow , Takafumi Tsuboi , Motomi Torii
CPC分类号： A61K31/70 , A61K39/002 , C07K14/445 , Y02A50/412
摘要： The present invention relates to novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
摘要翻译： 本发明涉及用于阻断疟原虫的间日疟原虫传播的新方法和组合物。 特别地，公开了Pvs25和Pvs28多肽，变体，包括去糖基化形式及其融合蛋白，其当被施用于易感生物体时分别在疟原虫表面上诱导针对25kD和28kD蛋白的免疫应答 间日ax z和ookinetes。 易感生物体内的这种免疫应答可以阻止疟疾传播。
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公开(公告)号：US20080274132A1
公开(公告)日：2008-11-06
申请号：US12167178
申请日：2008-07-02
申请人： David C. KASLOW , Takafumi Tsuboi , Motomi Torii
发明人： David C. KASLOW , Takafumi Tsuboi , Motomi Torii
CPC分类号： C07K14/445 , A61K38/00 , C07K2319/00 , Y02A50/412 , Y02A50/58
摘要： The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
摘要翻译： 本发明涉及用于阻断疟原虫的间日疟原虫传播的新方法和组合物。 特别地，公开了Pvs25和Pvs28多肽，变体，包括去糖基化形式及其融合蛋白，其当被施用于易感生物体时分别在疟原虫表面上诱导针对25kD和28kD蛋白的免疫应答 间日ax z和ookinetes。 易感生物体内的这种免疫应答可以阻止疟疾传播。
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公开(公告)号：US20130149317A1
公开(公告)日：2013-06-13
申请号：US13809462
申请日：2011-07-04
申请人： Takafumi Tsuboi , Motomi Torii , Tatsuya Sawasaki , Yaeta Endo
发明人： Takafumi Tsuboi , Motomi Torii , Tatsuya Sawasaki , Yaeta Endo
IPC分类号： A61K39/015 , A61K39/395
CPC分类号： A61K39/015 , A61K39/39575 , A61K2039/507 , C07K14/445 , C07K16/205 , Y02A50/412
摘要： The present invention relates to a malaria vaccine comprising:(a) a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3;(b) a polypeptide consisting of an amino acid sequence of SEQ ID NO: 1, 2, or 3, wherein one or more amino acids are deleted, substituted and/or added and having effect for preventing falciparum malaria; or(c) a polypeptide consisting of an amino acid sequence having 70% or more identity with an amino acid sequence of SEQ ID NO: 1, 2, or 3 and having effect for preventing falciparum malaria.
摘要翻译： 本发明涉及疟疾疫苗，其包含：（a）由SEQ ID NO：1,2或3的氨基酸序列组成的多肽; （b）由SEQ ID NO：1,2或3的氨基酸序列组成的多肽，其中一个或多个氨基酸被缺失，取代和/或添加并具有预防恶性疟原虫的作用; 或（c）由与SEQ ID NO：1,2或3的氨基酸序列具有70％以上同一性并具有预防恶性疟原虫疟疾作用的氨基酸序列组成的多肽。
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公开(公告)号：US20070110772A1
公开(公告)日：2007-05-17
申请号：US11611779
申请日：2006-12-15
申请人： David Kaslow , Takafumi Tsuboi , Motomi Torii
发明人： David Kaslow , Takafumi Tsuboi , Motomi Torii
IPC分类号： A61K48/00 , A61K39/015
CPC分类号： A61K39/015 , C07K16/205 , Y02A50/412
摘要： The present invention relates novel methods and compositions for blocking transmission of Plasmodium vivax which cause malaria. In particular, Pvs25 and Pvs28 polypeptides, variants, including deglycosylated forms, and fusion proteins thereof, are disclosed which, when administered to a susceptible organism, induce an immune response against a 25 kD and 28 kD protein, respectively, on the surface of Plasmodium vivax zygotes and ookinetes. This immune response in the susceptible organism can block transmission of malaria.
摘要翻译： 本发明涉及用于阻断疟原虫的间日疟原虫传播的新方法和组合物。 特别地，公开了Pvs25和Pvs28多肽，变体，包括去糖基化形式及其融合蛋白，其当被施用于易感生物体时分别在疟原虫表面上诱导针对25kD和28kD蛋白的免疫应答 间日ax z和ookinetes。 易感生物体内的这种免疫应答可以阻止疟疾传播。
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公开(公告)号：US20060233789A1
公开(公告)日：2006-10-19
申请号：US10572139
申请日：2004-09-24
申请人： Yaeta Endo , Takafumi Tsuboi , Motomi Torii , Tatsuya Sawasaki
发明人： Yaeta Endo , Takafumi Tsuboi , Motomi Torii , Tatsuya Sawasaki
IPC分类号： A61K39/395 , A61K39/00 , G01N33/53 , A61K36/899 , C07K16/18
CPC分类号： C07K14/445 , G01N33/56905 , G01N2333/445 , Y02A50/412
摘要： An object of the present invention is to provide a means for producing an antigenic component with the retained native antigenicity using a cell-free protein synthesis. In particular, it is an object to provide a means for producing an antigenic component without depending on codon usage, like expressing an antigenic component from a gene containing a large amount of AT. The present inventors have made a strenuous study to solve the matters described above and successfully completed the present invention by preparing an antigenic component with the retained antigenicity, in particular a malaria antigen useful for manufacturing a malaria vaccine, through a system with the use of a wheat embryo among cell-free protein synthesis means.
摘要翻译： 本发明的目的是提供一种使用无细胞蛋白质合成制备具有保留的天然抗原性的抗原成分的方法。 特别地，本发明的目的是提供一种不依赖于密码子使用的抗原成分的制造方法，如从含有大量AT的基因表达抗原成分。 本发明人为了解决上述问题而进行了艰苦的研究，并通过制备具有保留的抗原性的抗原成分，特别是用于制造疟疾疫苗的疟疾抗原，通过使用 小麦胚胎无细胞蛋白质合成手段。
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