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公开(公告)号：US10602740B2
公开(公告)日：2020-03-31
申请号：US13545281
申请日：2012-07-10
申请人： David Kravitz , Christopher P. Steinman , Jeffrey S. Louis , Matthew Copithorne , Brian L. Otts , Peter Demuylder
发明人： David Kravitz , Christopher P. Steinman , Jeffrey S. Louis , Matthew Copithorne , Brian L. Otts , Peter Demuylder
IPC分类号： A01N1/02
摘要： An organ perfusion apparatus may include at least two tubes connected to an organ or tissue. A method of perfusing an organ or tissue may include connecting a first end of each of the at least two tubes to an organ or tissue, applying a fluid motive force to a perfusion fluid in the two tubes to force the fluid through the two tubes into the organ or tissue, and perfusing the organ or tissue through the at least two tubes such that the fluid motive force, provided by, e.g., a pump, and backpressure generated by the organ or tissue, establishes a flow balance between the at least two tubes. The flow balance may be altered without altering the fluid motive force that is applied.
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公开(公告)号：USD693937S1
公开(公告)日：2013-11-19
申请号：US29426699
申请日：2012-07-10
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公开(公告)号：US09357767B2
公开(公告)日：2016-06-07
申请号：US13545321
申请日：2012-07-10
申请人： Christopher P. Steinman , Rick W. Walker , Kirk C. Palmerton , Jeffrey S. Louis , David Pettinato , Matthew Copithorne , Brian L Otts , Peter Demuylder , James Guarrera , Ben O. Arrington
发明人： Christopher P. Steinman , Rick W. Walker , Kirk C. Palmerton , Jeffrey S. Louis , David Pettinato , Matthew Copithorne , Brian L Otts , Peter Demuylder , James Guarrera , Ben O. Arrington
IPC分类号： A01N1/02
CPC分类号： A01N1/0247 , A01N1/0273
摘要： A perfusion apparatus includes a coolant container having a basin-receiving recess that is at least partly surrounded by an inner chamber; a basin that is shaped to fit within the basin-receiving recess of the coolant container; and a cradle that is shaped to accept an organ and fit within the basin. The basin-receiving recess of the coolant container, the basin and the cradle each have positioning elements that are oriented such that the cradle is keyed to fit within the basin and the basin is keyed to fit within the coolant container, each in a single predetermined orientation. The plurality of positioning elements on the basin may include a plurality of protrusions on an outer surface of the basin.
摘要翻译： 灌注装置包括：冷却剂容器，其具有至少部分地被内腔包围的盆容纳凹部; 成形为容纳在冷却剂容器的盆接收凹部内的盆; 和一个成形为接受器官并装配在盆内的摇篮。 冷却剂容器，盆和托架的盆容纳凹槽各自具有定位元件，其定位成使得支架被键合以配合在盆内，并且盆被键合以装配在冷却剂容器内，每个以单个预定的 方向。 盆上的多个定位元件可以包括在盆的外表面上的多个突起。
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公开(公告)号：USD692577S1
公开(公告)日：2013-10-29
申请号：US29426757
申请日：2012-07-10
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公开(公告)号：USD692576S1
公开(公告)日：2013-10-29
申请号：US29426749
申请日：2012-07-10
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公开(公告)号：USD685498S1
公开(公告)日：2013-07-02
申请号：US29426748
申请日：2012-07-10
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7.发明授权公开(公告)号：US09565853B2
公开(公告)日：2017-02-14
申请号：US13545060
申请日：2012-07-10
申请人： Christopher P. Steinman , Jeffrey S. Louis , Rick W. Walker , Evan D. Shapiro , Aaron R. Ferber , Rodney H. Monson , John Stark , Ross Lockwood
发明人： Christopher P. Steinman , Jeffrey S. Louis , Rick W. Walker , Evan D. Shapiro , Aaron R. Ferber , Rodney H. Monson , John Stark , Ross Lockwood
CPC分类号： A01N1/0247 , A61M1/3627 , A61M1/3638 , A61M5/36
摘要： An apparatus for separating gas bubbles that may be entrained in perfusate flow prevents such bubbles from continuing downstream and entering an organ or tissue. The apparatus may include a chamber having a top wall, a bottom wall and side walls. The chamber may include an inlet configured to allow at least one of gas and liquid to enter the chamber, an air opening configured to allow at least gas to exit the chamber and a first liquid opening configured to allow at least liquid to exit the chamber. The apparatus may function as an accumulator that reduces or eliminates pulsatility of the liquid flow and pressure. The apparatus may include a minimum volume of gas, initially or through the accumulation of gas, such that flow and pressure fluctuations in the liquid are dampened or eliminated. The apparatus may include a sampling port in a wall of the chamber.
摘要翻译： 用于分离可能夹带在灌注液中的气泡的装置防止这种气泡继续下游并进入器官或组织。 该装置可以包括具有顶壁，底壁和侧壁的室。 腔室可以包括被配置为允许气体和液体中的至少一个进入腔室的入口，被配置为允许至少气体离开腔室的空气开口和被配置为允许至少液体离开腔室的第一液体开口。 该装置可以用作减少或消除液体流动和压力的脉动的蓄能器。 该装置可以包括最初体积的气体，最初或通过气体的积聚，使得液体中的流动和压力波动被抑制或消除。 该装置可以包括在该室的壁中的取样口。
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公开(公告)号：USD692573S1
公开(公告)日：2013-10-29
申请号：US29426725
申请日：2012-07-10
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公开(公告)号：USD692575S1
公开(公告)日：2013-10-29
申请号：US29426735
申请日：2012-07-10
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公开(公告)号：USD692574S1
公开(公告)日：2013-10-29
申请号：US29426729
申请日：2012-07-10
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