公开(公告)号：US5679394A

公开(公告)日：1997-10-21

申请号：US379249

申请日：1995-01-27

Applicant: David M. Long, Jr. ,  Raymond A. Long

Inventor： David M. Long, Jr. ,  Raymond A. Long

IPC: A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18

CPC classification number: A61K31/70 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48853 ,  A61K49/0433 ,  A61K49/0471 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1821 ,  Y10S514/814 ,  Y10S514/832 ,  Y10S514/963

Abstract: The present invention relates to a composition for increasing the vascular dwell-time of a particulate therapeutic or diagnostic agent in a mammal through the adjunct administration of an effective amount of the particulate therapeutic or diagnostic agent and an effective amount of a vascular dwell-time enhancing agent. Suitable therapeutic and diagnostic agents include those whose efficacy within the body is predicated on their ability to remain within or to be carried within the vascular compartment. Accordingly this method can be readily adapted for treating several diseases and disorders, including hypoxia, hypoxemia, anemia and cancer and for imaging selected regions of a mammal by various imaging techniques, including ultrasound imaging, X-ray imaging and MRI imaging.

Abstract translation: 本发明涉及一种用于通过辅助施用有效量的颗粒治疗或诊断剂和有效量的血管停留时间增强来增加哺乳动物中颗粒状治疗剂或诊断剂的血管停留时间的组合物 代理商 合适的治疗剂和诊断剂包括其在体内的功效取决于其保留在血管室内或在血管隔室内携带的能力的那些。 因此，该方法可以容易地适用于治疗几种疾病和障碍，包括缺氧，低氧血症，贫血和癌症，并且通过各种成像技术（包括超声成像，X射线成像和MRI成像）对哺乳动物的选定区域进行成像。

公开(公告)号：US5391376A

公开(公告)日：1995-02-21

申请号：US122192

申请日：1993-09-15

Applicant: David M. Long, Jr. ,  Raymond A. Long

Inventor： David M. Long, Jr. ,  Raymond A. Long

IPC: A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K31/33

CPC classification number: A61K31/70 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48853 ,  A61K49/0433 ,  A61K49/0471 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1821 ,  Y10S514/814 ,  Y10S514/832 ,  Y10S514/963

Abstract: The present invention relates to method for preventing or treating cachexia in a mammal based on the administration of a therapeutically effective amount of an anti-cachexia agent. Suitable agents include ADP-ribose-polymerase inhibitors, ADP-ribose-transferase inhibitors, NADase inhibitors, nicotinamide benzamide, theophylline, thymine and analogs thereof.

Abstract translation: 本发明涉及基于施用治疗有效量的抗恶病质剂来预防或治疗哺乳动物的恶病质的方法。 合适的试剂包括ADP-核糖聚合酶抑制剂，ADP-核糖转移酶抑制剂，NADase抑制剂，烟酰胺苯甲酰胺，茶碱，胸腺嘧啶及其类似物。

公开(公告)号：US5264220A

公开(公告)日：1993-11-23

申请号：US790855

申请日：1991-11-12

Applicant: David M. Long, Jr. ,  Raymond A. Long

Inventor： David M. Long, Jr. ,  Raymond A. Long

IPC: A61K9/107 ,  A61K9/127 ,  A61K9/16 ,  A61K9/50 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48 ,  A61K49/00 ,  A61K49/04 ,  A61K49/18 ,  A61K9/121

CPC classification number: A61K31/70 ,  A61K31/44 ,  A61K31/455 ,  A61K47/48853 ,  A61K49/0433 ,  A61K49/0471 ,  A61K49/1806 ,  A61K49/1812 ,  A61K49/1821 ,  Y10S514/814 ,  Y10S514/832 ,  Y10S514/963

Abstract: The present invention relates to a composition for increasing the vascular dwell-time of a particulate therapeutic or diagnostic agent in a mammal through the adjunct administration of an effective amount of the particulate therapeutic or diagnostic agent and an effective amount of a vascular dwell-time enhancing agent. Suitable therapeutic and diagnostic agents include those whose efficacy within the body is predicated on their ability to remain within or to be carried within the vascular compartment. Accordingly this method can be readily adapted for treating several diseases and disorders, including hypoxia, hypoxemia, anemia and cancer and for imaging selected regions of a mammal by various imaging techniques, including ultrasound imaging, X-ray imaging and MRI imaging.

Abstract translation: 本发明涉及一种用于通过辅助施用有效量的颗粒治疗或诊断剂和有效量的血管停留时间增强来增加哺乳动物中颗粒状治疗剂或诊断剂的血管停留时间的组合物 代理商 合适的治疗剂和诊断剂包括其在体内的功效取决于其保留在血管室内或在血管隔室内携带的能力的那些。 因此，该方法可以容易地适用于治疗几种疾病和障碍，包括缺氧，低氧血症，贫血和癌症，并且通过各种成像技术（包括超声成像，X射线成像和MRI成像）对哺乳动物的选定区域进行成像。

公开(公告)号：US06406389B1

公开(公告)日：2002-06-18

申请号：US09476855

申请日：2000-01-03

Applicant: Brian Feeney ,  Ronald P. LaLiberty ,  Raymond A. Long

Inventor： Brian Feeney ,  Ronald P. LaLiberty ,  Raymond A. Long

IPC: A63B4108

CPC classification number: A63B41/08

Abstract: A basketball formed from overlying layers includes a carcass layer with recessed curvilinearly extending seam areas. Ribs longitudinally follow the recessed seam areas and extend outwardly therefrom. Panels are mounted to the carcass between the ribs.

Abstract translation: 由覆盖层形成的篮子包括具有凹陷的曲线延伸的接缝区域的胎体层。 肋纵向跟随凹陷区域并从其向外延伸。 面板安装在肋骨之间的胎体上。