公开(公告)号：US20130261303A1

公开(公告)日：2013-10-03

申请号：US13905447

申请日：2013-05-30

申请人： David OVADIA ,  Raya STURKOVICH ,  David LEONOV

发明人： David OVADIA ,  Raya STURKOVICH ,  David LEONOV

IPC分类号： C07D239/52

CPC分类号： C07D239/52 ,  C07D239/54

摘要： The present invention provides a process for reacting between a phenol derivative and an aromatic substrate under phenolate forming conditions comprising the following steps: (a) reacting a phenol derivative with a base in a polar organic solvent to obtain a phenolate salt, wherein water is removed from the reaction mixture during the reaction, (b) adding the aromatic substrate to the reaction mixture obtained in step (a), (c) heating the reaction mixture of step (b) to a temperature in the range of 80° to 1300° C., preferably, 90° to 1000° C. for 2 to 7 hours to obtain a phenoxy substituted aromatic substrate, (d) removing the solvent from the mixture of step (c) and optionally further isolating and purifying the phenoxy substituted aromatic substrate. Optionally, the removal of water during step (a) is in conjunction with partial removal of the organic solvent.

摘要翻译： 本发明提供一种苯酚衍生物和芳族底物在酚盐形成条件下的反应方法，包括以下步骤：（a）使苯酚衍生物与碱在极性有机溶剂中反应得到酚盐，其中除去水 （b）将芳族底物加入到步骤（a）中获得的反应混合物中，（c）将步骤（b）的反应混合物加热至80℃至1300℃的温度 （d）从步骤（c）的混合物中除去溶剂，任选地进一步分离和纯化苯氧基取代的芳香族底物， 。 任选地，在步骤（a）期间除去水与有机溶剂的部分去除结合在一起。