公开(公告)号：US08410079B2

公开(公告)日：2013-04-02

申请号：US13226661

申请日：2011-09-07

申请人： David Wayne Peter ,  John Dillon Stanek ,  Cheria L. Orozco ,  Shyam K. Gupta

发明人： David Wayne Peter ,  John Dillon Stanek ,  Cheria L. Orozco ,  Shyam K. Gupta

IPC分类号： A61K9/00 ,  A61K8/02 ,  A61K31/665 ,  A01N57/00

CPC分类号： A61K8/19 ,  A61K8/498 ,  A61K8/55 ,  A61K31/675 ,  A61K31/7056 ,  A61K31/7076 ,  A61K31/7135 ,  A61K31/715 ,  A61K45/06 ,  A61K48/00 ,  A61Q5/006 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/004 ,  A61Q19/008 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08 ,  A61K2300/00

摘要： The present invention discloses certain chirally correct polyene cyclodextrin acetals and hemiacetals (formula I) that are effective in providing skin clarification, which is useful for the treatment of acne, and skin disfigurements and skin darkening resulting from acne; skin darkening from cancer, diabetes, radiation treatments, chemotherapy, and sun-burn; mitochondrial and DNA dysfunction; age spots; loss of cellular antioxidants; skin changes associated with aging including collagen loss, loss of skin pliability, loss of skin suppleness, skin wrinkles and fine lines, oxidation, damage from radiation, damage from free radicals, and damage from UV; dry skin; xerosis; ichthyosis; dandruff; brownish spots; keratoses; melasma; lentigines; liver spots; skin pigmentation including pigmented spots, dark circles under the eyes, darkened skin, and blemishes; oily skin; warts; eczema; pruritic skin; psoriasis; inflammatory dermatoses; topical inflammation; disturbed keratinization; scalp dryness, and combinations thereof;

公开(公告)号：US08569269B1

公开(公告)日：2013-10-29

申请号：US13919090

申请日：2013-06-17

申请人： David Wayne Peter ,  John Dillon Stanek ,  Shyam K Gupta

发明人： David Wayne Peter ,  John Dillon Stanek ,  Shyam K Gupta

IPC分类号： A01N57/00 ,  A61K31/665 ,  A61K31/66

CPC分类号： A61K45/06 ,  A61K8/671 ,  A61K8/738 ,  A61K31/724 ,  A61K48/00 ,  A61K2800/92 ,  A61Q5/006 ,  A61Q17/00 ,  A61Q19/00 ,  A61Q19/02 ,  A61Q19/04 ,  A61Q19/08

摘要： The present invention discloses a method of treating, reducing the occurrence of, or improving the symptoms associated with a skin condition by topical application of a compound of formula (I) or a salt thereof, wherein said skin condition is selected from the group consisting of melanogenesis, oxidative damage, inflammation, skin irritation from inflammation, loss of cell adhesion, loss of desquamation, extra-cellular including connective tissue matrix breakdown and skin tone loss thereof, loss of keratinization, cellular senescence, skin aging from cellular senescence, loss of skin whiteness, loss of skin barrier function, loss of skin firmness, rosacea, skin wrinkles and fine lines from cellular senescence, cellular oxidation, loss of skin collagen, topical wounds, and combinations thereof.

摘要翻译： 本发明公开了通过局部施用式（I）化合物或其盐来治疗，减少与皮肤病症有关的症状的发生或改善的方法，其中所述皮肤病症选自 黑素生成，氧化损伤，炎症，炎症皮肤刺激，细胞粘附丧失，脱屑丧失，细胞外包括结缔组织基质分解及其肤色丧失，角质化丧失，细胞衰老，细胞衰老引起的皮肤老化 皮肤白度，皮肤屏障功能丧失，皮肤紧致度丧失，红斑痤疮，皮肤皱纹和细胞衰老细胞，细胞氧化，皮肤胶原蛋白损失，局部伤口及其组合。