公开(公告)号：US20240120022A1

公开(公告)日：2024-04-11

申请号：US18275933

申请日：2022-01-27

Applicant: DeepMind Technologies Limited

Inventor： Andrew W. Senior ,  Simon Kohl ,  Jason Yim ,  Russell James Bates ,  Catalin-Dumitru Ionescu ,  Charlie Thomas Curtis Nash ,  Ali Razavi-Nematollahi ,  Alexander Pritzel ,  John Jumper

IPC: G16B15/00 ,  G16B30/20 ,  G16B40/20

CPC classification number: G16B15/00 ,  G16B30/20 ,  G16B40/20

Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.