公开(公告)号：US08076511B2

公开(公告)日：2011-12-13

申请号：US11750502

申请日：2007-05-18

申请人： Der-Shing Huang ,  Olivier Dapremont ,  Patrick Berget ,  Xa Her ,  Darin Sanchez

发明人： Der-Shing Huang ,  Olivier Dapremont ,  Patrick Berget ,  Xa Her ,  Darin Sanchez

IPC分类号： C07C51/42

CPC分类号： C07B57/00 ,  C07B2200/07 ,  C07C51/487 ,  C07C59/64 ,  C07C57/58 ,  C07C57/30

摘要： High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.

摘要翻译： 通过在酸性改性剂和疏水性溶剂中包含流动相中的叔醇，通过制备型色谱纯化手性羧酸的对映异构体获得高产率和纯度。 通过降低对映体的酯化程度，叔醇优于其它更常用的醇，否则会降低产率和纯度。

公开(公告)号：US20080287704A1

公开(公告)日：2008-11-20

申请号：US11750502

申请日：2007-05-18

申请人： Der-Shing Huang ,  Olivier Dapremont ,  Patrick Berget ,  Xa Her ,  Darin Sanchez

发明人： Der-Shing Huang ,  Olivier Dapremont ,  Patrick Berget ,  Xa Her ,  Darin Sanchez

IPC分类号： C07B55/00

CPC分类号： C07B57/00 ,  C07B2200/07 ,  C07C51/487 ,  C07C59/64 ,  C07C57/58 ,  C07C57/30

摘要： High yields and purity are obtained in the purification of enantiomers of chiral carboxylic acids by preparative-scale chromatography by including a tertiary alcohol in the mobile phase in conjunction with an acidic modifier and a hydrophobic solvent. The tertiary alcohol is superior to other, more commonly used alcohols by reducing the extent of esterification of the enantiomer that otherwise lowers the yield and the purity.

摘要翻译： 通过在酸性改性剂和疏水性溶剂中包含流动相中的叔醇，通过制备型色谱纯化手性羧酸的对映异构体获得高产率和纯度。 通过降低对映体的酯化程度，叔醇优于其它更常用的醇，否则会降低产率和纯度。