公开(公告)号：US20210139592A1

公开(公告)日：2021-05-13

申请号：US17256999

申请日：2019-07-14

Applicant: Development Center for Biotechnology

Inventor： Cheng-Chou YU ,  Shih-Rang YANG ,  Tsung-Han HSIEH ,  Mei-Chi CHAN ,  Shu-Ping YEH ,  Chuan-Lung HSU ,  Ling-Yueh HU ,  Chih-Lun HSIAO

IPC: C07K16/28 ,  A61K47/68

Abstract: An anti-PD-L1 antibody, or an antigen-binding fragment thereof, comprising: a heavy chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 2-4, 6-8, 10-12, 14-16, or 18-20; and/or a light chain variable region comprising the three CDRs with the sequences of SEQ ID NOs: 22-24, 26-28, 30-32, 34-36, or 38-40, wherein the antibody is a chimeric, humanized, composite, or human antibody.